DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and Mtmr1

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	XP_038952863.1	Gene:	Mtmr1 / 317296	RGDID:	1306569	Length:	681	Species:	Rattus norvegicus

Alignment Length:	836	Identity:	204/836 - (24%)
Similarity:	306/836 - (36%)	Gaps:	311/836 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   862 IGVTVGKTISRFIDCVCTEGGVTSEHI-------RNLHDMVPGVVHMHIESLEPVYLEAKRHPHV 919
            |..|:...:|         |.||||::       :..|:..|......         :|.|..:.
  Rat    61 IAATISTQMS---------GSVTSENVSRDYKELQEEHNGYPSAAEAD---------QALRDGNK 107

  Fly   920 QKPKIQTPCLLPGED---LVTDHLRCFLMPDGREDETQCLIPAEGALFLTNYRVIFKGSPCDPLF 981
            .....:.| |.|||.   :|.|.:  ::.|...        ...|.|.:|::::.||....||.|
  Rat   108 LAQMEEAP-LFPGESIKAIVKDVI--YICPFAG--------AVSGTLTVTDFKMFFKNVERDPHF 161

  Fly   982 CEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSFQLIKVAFDPEVTPEQIESFRKI 1046
            ...|     |:..:.:.:||..  .:|.|.:.  |:::.....:.:::|:..|   ||    ||:
  Rat   162 ILDV-----PLGVISRVEKIGA--QSHGDNSC--GIEIVCKDMRNLRLAYKQE---EQ----RKL 210

  Fly  1047 -----LSKARHPFDEFE-YFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRGAKKAGFKQKQ 1105
                 |:|...|....: .||| :|            |||:..               .|:|.
  Rat   211 GIFENLNKHAFPLSNGQALFAF-NY------------KEKFPV---------------NGWKV-- 245

  Fly  1106 QTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLTTKDVERMRERSYVQDWKRLG 1170
                     ||                             |                |.::||.|
  Rat   246 ---------YD-----------------------------P----------------VSEYKRQG 256

  Fly  1171 FDAESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHANG-ALL 1234
            ...||   ::||..|::|..|.:|||:||.|....|..::.:.......|:|:.:|.|... |.:
  Rat   257 LPNES---WKISKINSNYEFCDTYPAVIVVPTSVKDDDLLKVSAFRAKGRVPVLSWIHPESQATI 318

  Fly  1235 IRGGQ----PNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYSGMN 1295
            .|.||    ||.|                     ...|.:||...:::...:...|.:
  Rat   319 TRCGQPLVGPNDK---------------------RCKEDEKYLQTIMDANAQSHKLTI------- 355

  Fly  1296 LSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPKNSLAHPFRKMRLY 1360
                       .|.||.             .::|.||:..||.
  Rat   356 -----------FDARQN-------------SVADTNKAKGGGY---------------------- 374

  Fly  1361 ALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRACMP----SHNTNEADGQSFAKMVE 1421
               |...|..|      |:.|.::.|:|...|.:.:||.....|    ||..:..||
  Rat   375 ---ECESAYPN------AELIFLEIPNIHVMRESLRKLKEVVYPAIDESHWLSNVDG-------- 422

  Fly  1422 QSDWLQQISSLMQLSGAV--VDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRV 1484
             :.||:.|..|  |:|||  .|.|:..::||::...||.|.|.||:|:|.|.||.|||::.||..
  Rat   423 -THWLEYIRVL--LAGAVRIADKIESGKTSVVVHCSDGWDRTPQLTSLAMLMLDSYYRTIPGFEA 484

  Fly  1485 LVEKEWLAFGHRFAHRSNLKPSHANTNIAFA---PTFLQFLDVVHQLQRQFPMAFEFNDFYLRFL 1546
            |:||||::||||||    |:..|.:.|.|.|   |.||||:|.|.|:.||||.|||||:.:|..:
  Rat   485 LIEKEWISFGHRFA----LRVGHGDDNHADADRSPIFLQFIDCVWQMTRQFPSAFEFNELFLIAI 545

  Fly  1547 AYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGSDDECSVYPLDIRSQ 1611
            ..|..||.|.|||.:||.:|          .|..:.||.:
  Rat   546 LDHLYSCLFGTFLCNCEQQR----------VREDVCAKTL------------------------- 575

  Fly  1612 RAPAPLNRIGHSIFDYIERQHNKTPIFYN-FLYSGDKSVTLRPQNNVAALDLWCYY 1666
                       |::.||..|.::   |.| |..|.|..| |.|..:|:.|:||..|
  Rat   576 -----------SLWSYINSQLDE---FSNPFFVSYDHHV-LYPVASVSRLELWVNY 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	25/121 (21%)
		Myotub-related	1161..1565	CDD:284109	127/417 (30%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
Mtmr1	XP_038952863.1	PH-GRAM_MTMR1	123..222	CDD:270165	26/124 (21%)
Mtmr1	XP_038952863.1	Myotub-related	239..566	CDD:399535	133/508 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840