Protein Alignment Sbf and Mtmr10

DIOPT Version :10

• Sequence 1: NP_477401.2
• Gene: Sbf / 41427
• FlyBaseID: FBgn0025802
• Length: 1993
• Species: Drosophila melanogaster
• Sequence 2: NP_001094316.1
• Gene: Mtmr10 / 309255
• RGDID: 1305958
• Length: 771
• Species: Rattus norvegicus
• Alignment Length: 672
• Identity: 152/672 - (22%)
• Similarity: 250/672 - (37%)
• Gaps: 218/672 - (32%)

  Fly   921 KPKIQ--TPCLLPGEDLVTD---HLRCFLMPDGREDETQCLIPAEGAL-FLT---------NYRV 970
            :|||:  .|.|||||.:|.:   ..:|......:.|....||.:...: |:|         :||.
  Rat    28 EPKIKKLEPVLLPGEIVVNEVNFVRKCIATDTSQYDLWGKLICSNFKISFITDDPMPLQKFHYRN 92

  Fly   971 IFKGSPCDPLFC-EQVIVRTFPIASLLKEKKISVLYLAHLDQTL----TEGLQLRSSSFQLIKVA 1030
            :..|....||.| ||::.    :....:::|:     ...:|.|    || |.:....|::::..
  Rat    93 LLLGEHDVPLTCIEQIVT----VNDHKRKQKV-----LGPNQKLKFNPTE-LIIYCKDFRIVRFR 147

  Fly  1031 FDPEVTPEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRG 1095
            || |..||..:.....::....|.|....|||:..|            :||   ...|.|  :.|
  Rat   148 FD-ESGPESAKKVCLAIAHYSQPTDLQLLFAFEYVG------------KKY---HNSANK--VNG 194

  Fly  1096 AKKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLTTKDVERMRER 1160
            ....|.......          ||..:|.|..          |||.:
  Rat   195 VSSGGGGVWSGA----------GSPSSQRTPL----------FETYS------------------ 221

  Fly  1161 SYVQDWKRLGFDAESQR----GFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRI 1221
                ||     |.|::|    |:|:.:.|..|......|...|.|...:|..:......|.|:|:
  Rat   222 ----DW-----DRETKRTGASGWRVCSINEGYMISTCLPEYFVVPSSLADQDLKIFSPSFVGRRM 277

  Fly  1222 PLPTWRHANGALLIRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPL 1286
            |...|.|:||:.|:|         :.::|:..              :|.|....:.|.:.|
  Rat   278 PCWCWSHSNGSALVR---------MALIKDVL--------------QQRKIDQRICNAITK---- 315

  Fly  1287 ALNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPKNSLA 1351
                            .|          |:.|..:|::||.:
  Rat   316 ----------------SH----------PQRSDVYKSDLDKT----------------------- 331

  Fly  1352 HPFRKMRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRACM--PSHNTNEADGQ 1414
                                             .|:|::.:.||.||.:.|:  |...|.|
  Rat   332 ---------------------------------LPNIQEIQAAFVKLKQLCVNEPFEETEE---- 359

  Fly  1415 SFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSL 1479
            .:...:|.:.||:.:.:.::.|..:|.:::.|..||:|..|:|.|::..::|:.|:.:|||:|::
  Rat   360 KWLSSLESTRWLEYVRAFLKHSAELVYILESQRLSVVLQEEEGRDLSCLVASLVQVMMDPYFRTI 424

  Fly  1480 DGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLR 1544
            .||:.||:|||:..|:.|..|.|    |...:...:|.||.|||...||..|:|.||||::.||.
  Rat   425 TGFQSLVQKEWVMAGYPFLDRCN----HLKRSEKESPLFLLFLDTTWQLLEQYPAAFEFSETYLA 485

  Fly  1545 FLAYHSVSCRFRTFLFDCELER 1566
            .|...:....|.||||:...:|
  Rat   486 VLCDSTRISLFGTFLFNSPHQR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:460461
		dDENN	384..452	CDD:129037
		SBF2	584..807	CDD:463536
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	28/131 (21%)
		PTP-MTMR5-like	1179..1531	CDD:350382	76/353 (22%)
		C1_Sbf-like	1790..1840	CDD:410377
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
Mtmr10	NP_001094316.1	PH-GRAM_MTMR10	21..193	CDD:270154	46/192 (24%)
		PTP-MTMR10	275..468	CDD:350441	65/309 (21%)
		3-PAP	570..701	CDD:463634