DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and Mtmr7

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	XP_038950456.1	Gene:	Mtmr7 / 306490	RGDID:	1306608	Length:	672	Species:	Rattus norvegicus

Alignment Length:	844	Identity:	173/844 - (20%)
Similarity:	302/844 - (35%)	Gaps:	298/844 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   937 TDHLRCFLMPDGRE---------DETQCLIPAEGALFLTNYRVIFKGSPCDPLFCEQVIVRTFPI 992
            |.:.||.|......         |...|...|.|.|:||...|||              |...|
  Rat     5 TLYRRCLLWMSAARVMVENVRLVDRVSCKKAALGTLYLTATHVIF--------------VENAP- 54

  Fly   993 ASLLKEKKISVLYLAHLDQTLTEG----LQLRSSSFQLIKVAFDPEVTPEQIESFRKILSKARHP 1053
             ...||..|....::.:::..|..    |.:|..:||::::     |.|::.:
  Rat    55 -DTRKETWILHSQISTIEKQATTATGCPLLIRCKNFQIVQL-----VIPQERD------------ 101

  Fly  1054 FDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYG 1118
                   ....|.::::...|::.:|.|.                ..|..|
  Rat   102 -------CHDVYVSLIRLARPVRYEELYC----------------FSFNPK-------------- 129

  Fly  1119 SADAQETQSIDDELEDGDEFETQNNAMPRLLTTKDVERMRERSYV-----QDWKRLGFDAESQRG 1178
             .|.:|                                 ||:.::     :::||:|.   ....
  Rat   130 -LDKEE---------------------------------REQGWLLVDLSEEYKRMGL---PDNY 157

  Fly  1179 FRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIP-LPTWRHANGALLIRGGQPNS 1242
            :::|:.|..|..|.|||..:..|...:...|:...:....:|.| |..:...:.|.:.|..||.|
  Rat   158 WQLSDVNRDYRVCDSYPTELYVPRSATAHIIVGSSKFRSRRRFPALSYYCKESHASICRSSQPLS 222

  Fly  1243 ---------KSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYSGMNLSM 1298
                     :.::..::...             |..|  |:.:::|.|||..:|
  Rat   223 GFSARCLEDEQMLQAIRKAN-------------PRSD--FIYVVDTRPKLNAMA----------- 261

  Fly  1299 SSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPKNSLAHPFRKMRLYALG 1363
                                            |:::  |||...:.|              |:
  Rat   262 --------------------------------NRAA--GKGYENEDN--------------YS-- 276

  Fly  1364 EKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRAC---MPSHNTNEADGQSFAKMVEQSDW 1425
                     |:.|  .||.::  :|...|.:.:|::..|   .||.:       .|...:|.|.|
  Rat   277 ---------NIKF--QFIGIE--NIHVMRNSLQKMLEVCELKSPSMS-------DFLWGLENSGW 321

  Fly  1426 LQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEW 1490
            |:.|.::|.....:...:..:.:||::...||.|.|||:.|:|.|.||||||:|.||.||:||:|
  Rat   322 LRHIKAIMDAGIFIAKAVSEEGTSVLVHCSDGWDRTAQVCSVASLLLDPYYRTLKGFMVLIEKDW 386

  Fly  1491 LAFGHRFAHR-SNL--KPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVS 1552
            ::|||:|.|| .||  .|..      .:|...||::.|.||..|||.|||||:.:|..:.:|..|
  Rat   387 ISFGHKFNHRYGNLDGDPKE------ISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHVYS 445

  Fly  1553 CRFRTFLFDCELERSDSGIA---------AMEDKRGSLNAKHMFGAGGMATNGSDDECSVYPLDI 1608
            |:|..||.:.:.||.:..|.         ..:::...||.  :|.|....|.||          :
  Rat   446 CQFGNFLCNSQKERRELKIQERTYSLWSNLWKNRADYLNP--LFRADHSQTQGS----------L 498

  Fly  1609 RSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSG-DKSVTLRPQNNVAALDLWCYYTNEELA 1672
            ....||                 :|.|..|:|.:|:. :|.  |:|:.:|..   :.....||..
  Rat   499 HLPTAP-----------------YNFTYKFWNGMYNRFEKG--LQPRQSVTD---YLMAVKEESQ 541

  Fly  1673 QGAPYDLEVTTVDDEIDLSETKGKRMVITAGYDNMEKCNPSAYVCLLSEVKQAETERGHLPQKW 1736
            |   .:.|:.::::.::    |.:::.:.......::..||.:    |....::....:.||.:
  Rat   542 Q---LEEELESLEERLE----KIQKVHLNGAKVKSKQSEPSKH----SGFSTSDNSTANTPQDY 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	26/122 (21%)
		Myotub-related	1161..1565	CDD:284109	106/424 (25%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
Mtmr7	XP_038950456.1	PH-like	21..115	CDD:418428	23/133 (17%)
Mtmr7	XP_038950456.1	PTP-MTMR7	144..445	CDD:350431	101/405 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349493
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840