DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and Mtmr3

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	XP_006251364.1	Gene:	Mtmr3 / 305482	RGDID:	1310972	Length:	1207	Species:	Rattus norvegicus

Alignment Length:	1244	Identity:	274/1244 - (22%)
Similarity:	434/1244 - (34%)	Gaps:	412/1244 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   924 IQTPCLLPGEDLVTDHLRCFLMPDGREDE-------------TQCLIPAEGALF-LTNYRVIFKG 974
            ||...:.|.:.|:            ||||             |:.:..||.|:. |:|||:..|
  Rat    12 IQANQIFPRKQLI------------REDENLQVPFLELHGESTEYVGRAEDAIIALSNYRLHIK- 63

  Fly   975 SPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSFQLIKVAFDPEV---- 1035
                                 .||.      |.::...|.|.::.| ..|||.....|.:|
  Rat    64 ---------------------FKES------LVNVPLQLIESVECR-DIFQLHLTCKDCKVIRCQ 100

  Fly  1036 --TPEQIESFRKILSKARHP---FDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRG 1095
              |.||.:.:.|.|:.|..|   .::...||:.::           ..|.|::
  Rat   101 FPTFEQCQDWLKRLNNAIRPPGKIEDLFSFAYHAW-----------CMEVYAS------------ 142

  Fly  1096 AKKAGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLTTKDVERMRER 1160
                   :|:|                           .||......:...|.  ..:||||
  Rat   143 -------EKEQ---------------------------HGDLCRPGEHVTSRF--KNEVERM--- 168

  Fly  1161 SYVQDWKRLGFDAESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPT 1225
                     |||..:  .:||||.|..|..|.|||..::.|...:|..:..:......:|||...
  Rat   169 ---------GFDMNN--AWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRIPAVI 222

  Fly  1226 WRH-ANGALLIRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALN 1289
            :|| :|||::.|.|||         :.:.....||  |..|          |:.::.|
  Rat   223 YRHQSNGAVIARCGQP---------EVSWWGWRNA--DDEH----------LVQSVAK------- 259

  Fly  1290 QYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHK-----NNLDISDGN-KSSQGGKGGTMKGNPKN 1348
                           :.:.|.|....::|.::.     |..|:||.. .:|.....||      .
  Rat   260 ---------------ACASDSQSSVGKVSTRNSCRGFPNAGDLSDVEFDASLSNASGT------E 303

  Fly  1349 SLAHPFRKM-----RLYALGEKSQAKSNMNVDFCADFIP------VDYPDIRQSRPAFKKLIRAC 1402
            |||...:|:     |.||....::||.....  |.::.|      :...:|...|.:|:.|...|
  Rat   304 SLALQPQKLLILDARSYAAAVANRAKGGGCE--CPEYYPNCEVVFMGMANIHSIRRSFQSLRLLC 366

  Fly  1403 MPSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSI 1467
                 |...|..::...:|.:.||..:|.|::.:..||..:|..:..|::...||.|.|.|:.::
  Rat   367 -----TQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDRDQRPVLVHCSDGWDRTPQIVAL 426

  Fly  1468 AQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNIAFAPTFLQFLDVVHQLQRQF 1532
            |:|.||||||:::||:||||.|||.|||:||.|.....:..:.| ...|.|||:||.||||||||
  Rat   427 AKLLLDPYYRTVEGFQVLVEMEWLDFGHKFADRCGHGENSDDLN-ERCPVFLQWLDCVHQLQRQF 490

  Fly  1533 PMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMA---- 1593
            |.:||||:.:|..|..|:.||.|.|||.:...||.:.     :.:..:.:...:..||..|
  Rat   491 PCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEK-----QTQERTCSVWSLLRAGNKAFKNL 550

  Fly  1594 --------------------------------TNGSDDECSVYPLDIRSQRAPAPLNRIGHS-IF 1625
                                            :..:||.|:.||....|...| ||:|:..: .|
  Rat   551 LYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPSTPTDDSCAPYPAPGTSPDEP-PLSRLPKTRSF 614

  Fly  1626 DYIE-----------------------RQHNKTPIFYNFLYSGDKSVTL----RPQNNVAALDLW 1663
            |.:.                       ::|.::....:|..||::...:    ||...:...:|.
  Rat   615 DNLTTTCDNMVPLASRRSSDPSLNEKWQEHGRSLELSSFAGSGEEVPAIDSLRRPSRLLGGAELS 679

  Fly  1664 C--------------YYTNEELAQGAP---YDLEVTTVDDEIDL---SETKGKRMVITAGYDNME 1708
            .              ..|.||.....|   ...||..|.:|..|   |.|..:...:......::
  Rat   680 VAAGVAEGQMENILQEATKEESGVEEPTHREHTEVPEVKEEAPLAKESRTAAQGSGVLYQEPQLD 744

  Fly  1709 KC------NPSAYVCLLSEVKQA---ETERGH------LPQKWLQVWNSLEVPQLEPVARNTS-- 1756
            ..      .||     ||...|.   ..|.||      ||.. |:..:|.|||..:|...|.:
  Rat   745 DATLRSHLGPS-----LSSFSQGIPEHREVGHSVLSSSLPAS-LRGEDSQEVPVEQPQVENIAED 803

  Fly  1757 ---------------LGNI-----------FVQTHQHKRSTLEIIMKGRLAGYQDKYFHPH---- 1791
                           ||..           |.....|..:::.::::.::........|..
  Rat   804 RENVVPAVPVDVKIGLGTSESSPLLPSQVPFETRGPHMNNSVHMLLEDKVKSESGPQLHHRPCLA 868

  Fly  1792 ---RFE-KHPYTTPTNCNHCTKLLWGPVGYRCMDCGNSYH-----------EKCTEHSMKNC--- 1838
               ||. |.............:..|..|.:|....||:..           :||.:..:.|.
  Rat   869 SSGRFSGKDMLPIAPEPRSAERPQWDSVLHRTSSPGNTLSLMMQAPCALPLDKCRQRIVCNGALE 933

  Fly  1839 TKYKAIDGAVG--------PPNVNMSQGDT------------ASIASSAATTARTSSHHFYNQFS 1883
            |:.||.:...|        .||.:.:.|:|            |:..|||.:.:|...|.:.|..|
  Rat   934 TENKASEQPAGFDTLQKYPTPNGHCANGETGRSKDSLSHQLSATSYSSAHSCSRNLHHKWLNSHS 998

  Fly  1884 SNVAENRTHE----GHLYKRGALLKGWKQRWFVLDSIKHQLRYYDTSE----DTAPKGIIEL--- 1937
            ...:...:.|    .||...|..:        ..|:|:.:||..::..    :|..|.:.||
  Rat   999 GRPSTTNSPEQPSRSHLDDDGMPV--------YTDTIQQRLRQIESGHQQEVETLKKQVQELKSR 1055

  Fly  1938 AEVQSVTAA 1946
            .|.|.:|::
  Rat  1056 LESQYLTSS 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	29/133 (22%)
		Myotub-related	1161..1565	CDD:284109	127/421 (30%)
		C1	1791..1838	CDD:237996	10/65 (15%)
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941	15/70 (21%)
		PH	1891..1992	CDD:278594	15/67 (22%)
Mtmr3	XP_006251364.1	PH-GRAM_MTMR3	23..116	CDD:270149	30/133 (23%)
		PTP-MTMR3	169..485	CDD:350434	106/374 (28%)
		FYVE_MTMR3	1115..1184	CDD:277271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840