DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and Sbf1

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	XP_038934802.1	Gene:	Sbf1 / 300147	RGDID:	1307090	Length:	1950	Species:	Rattus norvegicus

Alignment Length:	2038	Identity:	827/2038 - (40%)
Similarity:	1150/2038 - (56%)	Gaps:	286/2038 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 FCQPLGWSLSYEKQEPKFFVSVLTDIDANKHYCACLSFHETVAITQ----TRSVDDEDETI--GS 112
            ||||.||.|..|:..|.|||:|||||::.:||||||:|.|.|..||    |....:::|..  |.
  Rat    97 FCQPSGWQLCPERNPPTFFVAVLTDINSERHYCACLTFWEPVESTQEVMCTEDATEKEEEAHGGG 161

  Fly   113 SRLLGATPSSMDGITTTSTPASITHHSVMYAPKCLVLISRLDCAETFKNCLGTIYTVYIENLAYG 177
            ...|.:|..:..|              .::|||.|||:||||.|:.|:|.||.|||:::|.|...
  Rat   162 QAQLSSTAPAQPG--------------QLFAPKTLVLVSRLDHADVFRNSLGLIYTIHVEGLNVN 212

  Fly   178 LETLIGNILGCIQVPPAGGPQV--------RFSIGAGDKQSLQPPQSSSLPTTGSGVHFLFKQLG 234
            ||.:|||:|.| .||.|||.|:        ..|:||||:|.:|.|...|||.:...|..||:|||
  Rat   213 LENVIGNLLTC-TVPLAGGSQLDSVEEGARTISLGAGDRQVIQTPLVDSLPVSRCSVALLFRQLG 276

  Fly   235 IKNVLILLCSVMTENKILFLSKCYWHLTDSCRALVALMYPFRYTHVYIPILPAPLTEVLSTPTPF 299
            |.|||.|.|:.:||:|:||||:.|..|.|:||.|:||::|.||:..|:|||||.|.|||||||||
  Rat   277 ITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPF 341

  Fly   300 IMGIHSSLQTEITDLLDVIVVDLDGGLVTIPESLTPPVPILPSPLWEQTQDLLSMILFPNLAQAD 364
            |:|::::.|.|..:||||||.|||||.||:||.:  .:|.||.||..||.::|||:|.|.|..||
  Rat   342 IIGVNAAFQAETQELLDVIVADLDGGTVTVPECV--HIPPLPEPLQSQTHNVLSMVLDPELELAD 404

  Fly   365 LAFPTLERPSAIAKTDAQIDKELRAIFMRLFAQLLQGYRSCLTIIRIHPKPVITFHKAGFLGARD 429
            ||||.   |:..|.:....||||||:|:|||||||||||.||.|:||||:|||.||||.|||.|.
  Rat   405 LAFPP---PTTSASSLKMQDKELRAVFLRLFAQLLQGYRWCLHIVRIHPEPVIRFHKAAFLGQRG 466

  Fly   430 LIESEFLFRVLDSMFFTTFVNERGPPWRSSDAWDELYSSMNELLKSEAQNRNLVGRTQRFKGYFN 494
            |:|.:||.:||:.|.|..||:|||.|:||:|.:|||.:  :|:.:..|...:
  Rat   467 LVEDDFLMKVLEGMAFAGFVSERGVPYRSTDLFDELVA--HEVARMRADENH------------- 516

  Fly   495 FTFPSYFQILTHIQELGRVLYENEGTLAHISYAQKVLRPPEGA-FQRIHQPAFPRISSEKVELII 558
               |  .::|.|:|||...||:||.....:: ..||.||.|.: .:|.|:| |||:....|:.|:
  Rat   517 ---P--HRVLRHVQELAEQLYKNENPYPAVA-MHKVQRPGEASHLRRTHRP-FPRLDEGTVQWIV 574

  Fly   559 QEGIRK-NGVPQRFHVTRNQHRIIPMGPRLPEALD--VRPNVQNSARRLEVLRICVSYIFENRIT 620
            .:...| .|.|..  |...:...:|.||.:...|:  ..|:: ||||||||:|.|:||:||.::.
  Rat   575 DQAAAKMQGAPPA--VKAERRTTVPSGPPMTAILERCSGPHI-NSARRLEVVRNCISYVFEGKML 636

  Fly   621 DARKLLPAVMRTLMHRDARLILCREFFGYVHGNKAVLDHQQFELVVRFMNKALQKSSGIDEYTVA 685
            :|:||||||:|.|..|.||..|..|...:|..|:||||||||:.|||.||..||..:.:||:.:|
  Rat   637 EAKKLLPAVLRALKGRAARRCLAHELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIA 701

  Fly   686 AALLPMSTIFCRKLSTGVVQFAYTEIQDHAIWKNLQFWESTFFQDVQGQIKALYL-------LHR 743
            |||||:.|.||||||.||.||||:.:|:|.:|...||||:.|:.|||..|:||||       ..:
  Rat   702 AALLPLVTAFCRKLSPGVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPSDGVSPTQ 766

  Fly   744 RQNEHQKEANCVLDEVPLEEPTALEITAEQLRKSPNIEEEKKAELAKSEESTLYSQAIHFANRMV 808
            ...|.|.:.         :|.:||::.:||.|..|.:..||:.||.:.||||::|||||:||||.
  Rat   767 ETGEAQSQD---------DERSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRMS 822

  Fly   809 SLLIPLDVNVDAASKPKPAF-RLE--ENQSVSNSIMGSHSLSEHSDEGFEENNALEIGVTVGKTI 870
            .||:|||.:.....:.:... .||  .|..|:||:.||.:.|..::.|||:....::...|.:.|
  Rat   823 YLLLPLDSSKSRLLRERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVVRFI 887

  Fly   871 SRFIDCVCTEGGVTSEHIRNLHDMVPGVVHMHIESLEPVYLEAKRHPHVQKPKIQTPCLLPGEDL 935
            :||:|.||||.||||:|::.||.|||.:|.||||:||.|:.|:||.|.:||||:..|.|||||:.
  Rat   888 NRFVDKVCTESGVTSDHLKGLHVMVPDIVQMHIETLEAVHRESKRLPPIQKPKLLRPRLLPGEEC 952

  Fly   936 VTDHLRCFLMPDGREDET------QCLIPAEGALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIAS 994
            |.|.||.:|:|||||:..      ..|:|||||:|||.|||||.|.|.|||..|||:||:||:|:
  Rat   953 VLDGLRVYLLPDGREEGVGGSGGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAA 1017

  Fly   995 LLKEKKISVLYLAHLDQTLTEGLQLRSSSFQLIKVAFDPEVTPEQIESFRKILSKARHPFDEFEY 1059
            |.|||:|||  ...:||.|.:||||||.:|||:|:|||.||..:..|.|||.|.|.|:|.|....
  Rat  1018 LTKEKRISV--QTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYPPDIRAT 1080

  Fly  1060 FAFQSYGTMLQGVAPLKTKEK---YSTLKGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSAD 1121
            |||.....:..|..|..||:|   :.||    .:.|::.|||...:|....|:.....:::....
  Rat  1081 FAFTLGSALTPGRPPRVTKDKGPSFRTL----SRNLVKNAKKTIGRQYVTRKKYNPPGWEHRGQP 1141

  Fly  1122 AQETQSIDDELEDGDEFETQNNAMPRLLT----TKDVERMR-----ERSYVQDWKRLGFDAES-- 1175
            ..|.|  :||:...:|.|      |..||    .|..:||.     ||:..:|::|||....|
  Rat  1142 PPEDQ--EDEISVSEELE------PSTLTPSSALKPSDRMTMSSLVERACCRDYQRLGLGTLSSS 1198

  Fly  1176 -----QRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHANG-ALL 1234
                 ...||||..|..||.|||||.:::.|....|.|:..:.||::..|.|:..||.... |:|
  Rat  1199 LSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSIQDNALQRVSRCYRQNRFPVVCWRSGRSKAVL 1263

  Fly  1235 IRGGQPNSKSVIGMLK-NTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYSGMN--- 1295
            :|.|..:.|.|:|:.| ..|.|...|..|.:.. ||:||..|::::||:..     ..||.|
  Rat  1264 LRSGGLHGKGVVGLFKAQNTPSPGQAQADSSSL-EQEKYLQAVVSSMPRYA-----DSSGRNTLS 1322

  Fly  1296 -LSMSSLMGHSSSDDRQ------PLTPELSR----KHKNNLDISDGNKSSQGGK-GGTMKGN--- 1345
             .|.:.:.||..|...:      ||....||    :.|.:...:.|..|..|.. |..:.|.
  Rat  1323 SFSSAHMGGHVPSPRARVTTLSNPLAASASRWTASRGKWSSVRASGRSSGLGADVGSRLAGRDLL 1387

  Fly  1346 ---------PKNSLAHPFRKMRLYALGEKSQAKSNMNVDFCA--DFIPVDYPDIRQSRPAFKKLI 1399
                     |.:....| ::..||.:|:|:|.| .:..|...  :.:|::..:.||.:.:||||:
  Rat  1388 STPHTNGAPPDSGFLRP-QRAALYIIGDKAQLK-GVRPDPLQQWELVPIEVFEARQVKASFKKLL 1450

  Fly  1400 RACMPSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQL 1464
            :||:|.....|....||.:.:|.|:||.||..|:|:|..||:|:| ..|||::|||||.|:|.|:
  Rat  1451 KACVPGCPATEPSPASFLRSLEDSEWLIQIHKLLQISVLVVELLD-SGSSVLVSLEDGWDITTQV 1514

  Fly  1465 SSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSH--ANTNIAFAPTFLQFLDVVHQ 1527
            .|:.||..||:||:|:|||:|||||||:|||||:||.    :|  |..:..|.|.||||||.|||
  Rat  1515 VSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRG----AHTLAGQSSGFTPVFLQFLDCVHQ 1575

  Fly  1528 LQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIAAME--DKRGSLNAKHMFGAG 1590
            :..||||.|||:.|||:||.||..|.||||||.|.:.||.:.|:...|  ::||.|..|
  Rat  1576 VHLQFPMEFEFSQFYLKFLGYHHTSRRFRTFLLDSDYERIELGLLYEEKGERRGQLACK------ 1634

  Fly  1591 GMATNGSDDECSVYPLDIRSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSGDKSVTLRPQN 1655
                                            |:::|::|...:||:|||:.|:.:.:..|||.:
  Rat  1635 --------------------------------SVWEYVDRLSKRTPMFYNYTYAPEDTEVLRPYS 1667

  Fly  1656 NVAALDLWCYYTNEELAQGAPYDLEVT------TVDDEIDLSETKGKRMVITAGYDNMEKCNPSA 1714
            ||:.|.:|.:||.|.||:|.|||.|:.      ..::..|....:.:|.|:...||:..:..|.|
  Rat  1668 NVSNLKVWDFYTEETLAEGPPYDWELAQGPPEPPEEERPDGGAPQSRRRVVWPCYDSRPRVQPDA 1732

  Fly  1715 YVCLLSEVKQAETERGHLPQKWLQVWNSLEVPQ-LEPVARNTSLG---NIFVQTHQHKRSTLEII 1775
            ...||.|:::.|||.|...::|.:.|:.::..| ||  .|....|   ::.|....|.|.:|.:.
  Rat  1733 ISRLLEELQRLETELGRPSERWKETWDRVKAAQRLE--GRQDGRGTPSSLLVSAVPHHRRSLGVY 1795

  Fly  1776 MKGRLAGYQDKYFHPHRFEKHPYTTPTNCNHCTKLLWGPVGYRCMDCGNSYHEKCTEHSMKNCTK 1840
            ::.                                  ||||                     .|.
  Rat  1796 LQE----------------------------------GPVG---------------------STL 1805

  Fly  1841 YKAIDGAVGPPNVNMSQGDTASIASSAATTARTSSHHFYNQFSSNVAENRTHEGHLYKRGALLKG 1905
            ..::|.       :.|.|.|   .||:...||.|:...|:||.:..:|||::||.|||:||.:|.
  Rat  1806 SLSLDS-------DQSSGST---TSSSRQAARRSTSTLYSQFQTAESENRSYEGTLYKKGAFMKP 1860

  Fly  1906 WKQRWFVLDSIKHQLRYYDTSEDTAPKGIIELAEVQSVTAAQPAQIGA-KGVDEKGFFDLKTSKR 1969
            ||.||||||..||||||||...||..||:|:||||::|....|. ||| |.||||.|||:||::|
  Rat  1861 WKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPT-IGAPKTVDEKAFFDVKTTRR 1924

  Fly  1970 IYNFYAINANLAQEWIEKLQACL 1992
            :|||.|.:...||:|::::|:||
  Rat  1925 VYNFCAQDVPSAQQWVDRIQSCL 1947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824	23/36 (64%)
		DENN	142..325	CDD:280329	103/190 (54%)
		dDENN	384..452	CDD:129037	46/67 (69%)
		SBF2	585..807	CDD:289132	109/230 (47%)
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	67/119 (56%)
		Myotub-related	1161..1565	CDD:284109	168/443 (38%)
		C1	1791..1838	CDD:237996	4/46 (9%)
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941	62/106 (58%)
		PH	1891..1992	CDD:278594	57/101 (56%)
Sbf1	XP_038934802.1	uDENN	<97..132	CDD:397495	21/34 (62%)
		DENN	178..367	CDD:214823	103/189 (54%)
		dDENN	421..489	CDD:129037	46/67 (69%)
		SBF2	600..821	CDD:403522	109/230 (47%)
		PH-like	950..1068	CDD:418428	67/119 (56%)
		PTP_DSP_cys	1207..1579	CDD:421693	141/384 (37%)
		PH_Sbf1_hMTMR5	1843..1948	CDD:269941	62/106 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349504
Domainoid	1	1.000	266	1.000	Domainoid score	I1816
eggNOG	1	0.900	-	-		E1_KOG1090
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1404	1.000	Inparanoid score	I111
OMA	1	1.010	-	-		QHG45747
OrthoDB	1	1.010	-	-		D11535at33208
OrthoFinder	1	1.000	-	-		FOG0003022
OrthoInspector	1	1.000	-	-		otm46095
orthoMCL	1	0.900	-	-		OOG6_104786
Panther	1	1.100	-	-	LDO	PTHR10807
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2012
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810