DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and Mtmr4

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	XP_006532446.1	Gene:	Mtmr4 / 170749	MGIID:	2180699	Length:	1204	Species:	Mus musculus

Alignment Length:	995	Identity:	219/995 - (22%)
Similarity:	367/995 - (36%)	Gaps:	296/995 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   924 IQTPCLLPGEDLVTDHLRCFLMPDGREDETQ---CLIPAEGALFL----------TNYRVIFKGS 975
            ||...|.|.::||.:           |:..|   .::..||..||          :|||:..|
Mouse    26 IQAKDLFPPKELVKE-----------EENLQVPFTVLQGEGVEFLGRATDALIAISNYRLHIK-- 77

  Fly   976 PCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSFQLIKVAFDPEVTPEQI 1040
                 |.:.||.....:...::.:.:..|::|..|.             ::::..|.   |.:|.
Mouse    78 -----FKDSVINVPLRMIDSVESRDMFQLHIACKDS-------------KVVRCHFS---TFKQC 121

  Fly  1041 ESFRKILSKA-RHPFDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRGAKKAGFKQK 1104
            :.:...||:| ..|....:.||| :|.....|   |..:::::.|
Mouse   122 QEWLSRLSRATARPAKPEDLFAF-AYHAWCLG---LTEEDQHTHL-------------------- 162

  Fly  1105 QQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLTTKDVERMRERSYVQDWKRL 1169
                                       .:.|:....:..|                    :..|:
Mouse   163 ---------------------------CQPGEHIRCRQEA--------------------ELARM 180

  Fly  1170 GFDAESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRH-ANGAL 1233
            |||.  |..:|:|:.|::|..|.|||..::.||..:|..:.::......:|||:..:|| .|||.
Mouse   181 GFDL--QNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAA 243

  Fly  1234 LIRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYSGMNLSM 1298
            :.|..||         :.:.....||         .|:|.:..|.....|.|  ..:.||.:||.
Mouse   244 IARCSQP---------EISWWGWRNA---------DDEYLVTSIAKACALDP--GTRASGGSLST 288

  Fly  1299 SSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPKNSLAHPFRKMRLYALG 1363
            .:.....:.|                   :|.:.|.....|......|:..|   ....|.|...
Mouse   289 GTNDASEACD-------------------TDFDSSLTACSGVESTAAPQKLL---ILDARSYTAA 331

  Fly  1364 EKSQAKSNMNVDFCADFIP------VDYPDIRQSRPAFKKLIRAC--MPSHNTNEADGQSFAKMV 1420
            ..::||.....  |.::.|      :...:|...|.:|:.|...|  ||       |..::...:
Mouse   332 VANRAKGGGCE--CEEYYPNCEVLFMGMANIHAIRNSFQYLRAVCSQMP-------DPSNWLSAL 387

  Fly  1421 EQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVL 1485
            |.:.|||.:|.:::.:..|.:.:|.:...|::...||.|.|.|:.::|::.||||||:|:||:||
Mouse   388 ESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVL 452

  Fly  1486 VEKEWLAFGHRF----AHRSNLKPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFL 1546
            ||.:||.|||:|    .|:.|.:..:..     .|.|||:||.||||.:|||..||||:.:|..|
Mouse   453 VESDWLDFGHKFGDRCGHQENAEDQNEQ-----CPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKL 512

  Fly  1547 AYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGSDDECSVYPLDIRSQ 1611
            ..|:.||.:.|||.:...||....|.    ||                     .|||:.|
Mouse   513 VQHTYSCLYGTFLANNPCEREKRNIY----KR---------------------TCSVWAL----- 547

  Fly  1612 RAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSGDKSVTLRPQNNVAALDLWCYYTNEELAQGAP 1676
                             .|..||.  |:||||:....|.|.|..:|.||.||   |...|...:|
Mouse   548 -----------------LRAGNKN--FHNFLYTPGSDVVLHPVCHVRALHLW---TAVYLPASSP 590

  Fly  1677 -------YDLEVTTVDDEIDLSETKGKRMVITAGYDN-MEKCNPSAYVCLLSE----VKQAETER 1729
                   .||.::.|....:.|.....|:..|...|: :..|:.|:.:...|.    ...::..|
Mouse   591 CTLGEENMDLYLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPLTRTSSDPNLNNHSQEVR 655

  Fly  1730 GHLPQKWLQVWNSLEVPQLEPVARNTSLGNIFVQTHQHKRSTLEIIMKGRLAGYQDKYFHPHRFE 1794
            |.     |:.|:|  .|:......::.:|:       .:.:..|:.:...|...|.:|.....|:
Mouse   656 GS-----LEPWHS--SPEGAETVIDSGVGS-------PQLTVGEMGLPPPLPSSQKEYLSNKPFK 706

  Fly  1795 KHPYTTPTNCNHCTKLLWGPVGYRCMDCGNSYHEKCTEHSMKNCTKYKAI--------------D 1845
            .|     .:|:         :.|:.::...|:..|.....:|...:.:|:              |
Mouse   707 GH-----KSCS---------LSYKLLNTSVSWEMKSNTSDIKVLEETEALAPDPSAQEEQGRTSD 757

  Fly  1846 GAVGPPNVNMSQGDTASIAS 1865
            |...||...:.:...:|:.|
Mouse   758 GLGKPPEQFLEKEAVSSLCS 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	21/126 (17%)
		Myotub-related	1161..1565	CDD:284109	118/416 (28%)
		C1	1791..1838	CDD:237996	7/46 (15%)
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
Mtmr4	XP_006532446.1	PH-GRAM_MTMR4	37..150	CDD:270150	29/147 (20%)
		PTP-MTMR4	186..493	CDD:350435	95/362 (26%)
		Atrophin-1	743..>863	CDD:367360	6/35 (17%)
		FYVE_MTMR4	1120..1179	CDD:277272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846045
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840