DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and mtmr7

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	XP_004911249.1	Gene:	mtmr7 / 100485851	XenbaseID:	XB-GENE-1008662	Length:	657	Species:	Xenopus tropicalis

Alignment Length:	770	Identity:	161/770 - (20%)
Similarity:	260/770 - (33%)	Gaps:	298/770 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   918 HVQKPKIQTPCLLPGEDLVTDHLRCFLMPDGREDETQCLIPAEGALFLTNYRVIFKGSPCDPLFC 982
            |::.||::...||                    |.......|.|.|:||...:||..:
Frog     3 HIRLPKVENVRLL--------------------DRISSRKAALGTLYLTGTHIIFVEN------- 40

  Fly   983 EQVIVRTFPIASLLKEKKISVLYLAHLDQ--TLTEG--LQLRSSSFQLIKVAFDPEVTPEQIESF 1043
                     |:...||..|....::.:::  |.|.|  :.:...:||:|::     :.|::.:..
Frog    41 ---------ISETRKETWILYSQISSIEKQATATSGCPILIHCKNFQVIQL-----IIPQERDCH 91

  Fly  1044 RKILSKARHPFDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRGAKKAGFKQKQQTK 1108
            ...||..|                       |....||..|..|:.|
Frog    92 DIYLSLVR-----------------------LSRPVKYEELYCFSFK------------------ 115

  Fly  1109 RKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLTTKDVERMRERSYVQDWKRLGFDA 1173
                                                 |.|..|:..|..:.....:::.|:|...
Frog   116 -------------------------------------PNLDKTEHEEGWKLVDLNEEYNRMGLPK 143

  Fly  1174 ESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIP-LPTWRHANGALLIRG 1237
            ..   :::|:.|..|..|.|||..:..|...:...|:...:.....|.| |..:...|.|.:.|.
Frog   144 SL---WQMSDVNRDYRVCDSYPTELYVPKSATVPIIVGSSKFRSRGRFPTLSYYCQDNNASICRS 205

  Fly  1238 GQP----------NSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYS 1292
            .||          :.:.:..:.|...||.                ||.:::|.|||..:| |:.:
Frog   206 SQPLSGFSARCLEDEQMLQAIRKANPGSD----------------FLYVVDTRPKLNAMA-NRAA 253

  Fly  1293 GMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPKNSLAHPFRKM 1357
            |        .|:.:.|              |..||
Frog   254 G--------KGYENED--------------NYSDI------------------------------ 266

  Fly  1358 RLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRAC---MPSHNTNEADGQSFAKM 1419
                   |.|            ||.::  :|...|.:.:|::..|   .||..       .|...
Frog   267 -------KFQ------------FIGIE--NIHVMRNSLQKMLEVCELRSPSMG-------DFLWG 303

  Fly  1420 VEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRV 1484
            :|.|.||:.|.:::.....:...:..:.:||::...||.|.|||:.|||.|.:|||||::.||.|
Frog   304 LESSGWLKHIKAIIDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSIASLLIDPYYRTIKGFMV 368

  Fly  1485 LVEKEWLAFGHRFAHR-SNL--KPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFL 1546
            |:||:|::|||:|.|| .||  .|...      :|...||::.|.||..|||.|||||:.:|..:
Frog   369 LIEKDWISFGHKFNHRYGNLDGDPKEV------SPVIDQFIECVWQLMEQFPCAFEFNERFLVHI 427

  Fly  1547 AYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGSDDECSVYPLDIRSQ 1611
            .:|..||::..||.:|:.||.                                       :||.|
Frog   428 HHHVYSCQYGNFLCNCQKERR---------------------------------------EIRVQ 453

  Fly  1612 RAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSGDKSV---TLRPQNNVAALDLW 1663
            ...       :|::.|:.:|...   :.|.||..|.|.   ||||..:.:....|
Frog   454 ERT-------YSLWSYLWKQRLD---YMNPLYRADHSQTQGTLRPNTSPSNFKFW 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	19/117 (16%)
		Myotub-related	1161..1565	CDD:284109	106/420 (25%)
		C1	1791..1838	CDD:237996
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
mtmr7	XP_004911249.1	PH-GRAM_MTMR7	1..103	CDD:270152	28/163 (17%)
mtmr7	XP_004911249.1	PTP-MTMR7	132..433	CDD:350431	101/406 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000