Protein Alignment HisCl1 and GLRA3

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_006520.2
• Gene: GLRA3 / 8001
• HGNCID: 4328
• Length: 464
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 165/476 - (34%)
• Similarity: 230/476 - (48%)
• Gaps: 92/476 - (19%)

  Fly    11 FRCLI--------ALAIYLHALEQSIQHCHCVHGYRNNTESAELVSHYESSLSLPDILPIPSKTY 67
            ||.|:        ||.:.|.|.::              |:||...|...|.....|.|...:..|
Human     7 FRTLVSGFYFWEAALLLSLVATKE--------------TDSARSRSAPMSPSDFLDKLMGRTSGY 57

  Fly    68 DKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVD 132
            |....|...|.|..|..::.:.|..||.|.:|.|..:|||.|.|.||||...|...:.   ||:|
Human    58 DARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDS---LDLD 119

  Fly   133 --WLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQI 195
              .|.|||:||.||.|.|...|||::..|..|.::.:..:||..:|||.|||.|..:::|.|.|.
Human   120 PSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQT 184

  Fly   196 CSMMIESLSHTVEDLVFIWNMTDPLVVNTEIELPQLDISN----NYTTDCTIEYSTGNFTCLAIV 256
            |.|.:||..:|:.||:|.|....|:.|...:.|||..:..    .|   ||..|:||.|||:.:.
Human   185 CIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRY---CTKHYNTGKFTCIEVR 246

  Fly   257 FNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVS 321
            |:|.|::||:|...||||.|||::||:||||..:|.||||.||:|::||:.||::.|:.|||.||
Human   247 FHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVS 311

  Fly   322 YVKAIDVWMSSCSVFVFLSLMEFAVVNNFMG-------------PVATKAMKGYSDENISDLDDL 373
            ||||||:||:.|.:|||.:|:|:|.| ||:.             ...|:|.........||:||
Human   312 YVKAIDIWMAVCLLFVFSALLEYAAV-NFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDMDD- 374

  Fly   374 KSALQHHRESIIEPQYDTFCHG-----------------HATAIY-----------------IDK 404
                     .:.|.::....:|                 |...:.                 ||.
Human   375 ---------EVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDT 430

  Fly   405 FSRFFFPFSFFILNIVYWTTF 425
            .||..||.:|.|.||.||..:
Human   431 ISRACFPLAFLIFNIFYWVIY 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	73/189 (39%)
		Cys-loop	182..196	CDD:349793	5/13 (38%)
		LGIC_TM_anion	265..>351	CDD:349851	50/85 (59%)
		TM1 helix	265..288	CDD:349851	14/22 (64%)
		TM2 helix	292..316	CDD:349851	12/23 (52%)
		TM3 helix	324..350	CDD:349851	14/25 (56%)
GLRA3	NP_006520.2	LIC	12..451	CDD:273305	162/469 (35%)