DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HisCl1 and Gabrq

DIOPT Version :10

Sequence 1:NP_731632.1 Gene:HisCl1 / 41426 FlyBaseID:FBgn0037950 Length:426 Species:Drosophila melanogaster
Sequence 2:NP_065234.1 Gene:Gabrq / 57249 MGIID:1888498 Length:638 Species:Mus musculus


Alignment Length:606 Identity:132/606 - (21%)
Similarity:218/606 - (35%) Gaps:237/606 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 HYESSLSLPDIL------------PIPSK-------TYDKNRAPKLLGQPTVVYFHVTVLSLDSI 94
            |:|.|.|.|:::            .:..|       |||....|...|.|..|...:.|.|::.|
Mouse    33 HFELSSSTPEVILDLFNCKNCANEAVVQKILDRVLSTYDVRLRPNFGGAPVPVSVSIYVSSIEQI 97

  Fly    95 NEESMTYVTDIFLAQSWRDPRLRLPE---NMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMS 156
            :|.:|.|...:||.|:|:|.||...|   |::..||:.:     .:|.|||:|.|:|....|:::
Mouse    98 SEINMDYTITMFLHQTWKDTRLAYYETNLNLTLDYRMHE-----KLWVPDCYFVNSKDAFVHDVT 157

  Fly   157 IPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNMTDPLV 221
            :.|....|:.|.|:.|..:||...:|::..:.:|.|.|.|.:.:||..:||||:|..|...:.:.
Mouse   158 VENRVFQLHPDGTVRYGIRLTTTAACSLDLQKFPMDKQSCKLEVESYGYTVEDIVLSWEDDNAIH 222

  Fly   222 VNTEIELPQLDISNNYTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFW 286
            :...:.:||........|...:.:.||::..|.:.|.::|.:..:|...|.|:.|..::||||||
Mouse   223 ITDGLHIPQYTYLGRTITSKEVYFYTGSYMRLIVKFQVQREVRSYLVQVYWPTVLTTILSWISFW 287

  Fly   287 IKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFM 351
            :..::..||||:|:||:|.|.|.::..:..||.:|.:||||:::..|..||||||:|:..:|...
Mouse   288 MNYDSSAARVTIGLTSILVLTTIDSHMRDKLPHISCIKAIDIYILVCLFFVFLSLLEYVYINYLF 352

  Fly   352 -----------------------------------------------GPVATKAMKGY------- 362
                                                           ||:....|:.:       
Mouse   353 FSQVPRRNHRRCRKPRRVVARYRYQEVVVANVQDGLINVEDRVEDRAGPLPDSPMQAHLASQESL 417

  Fly   363 -------------------------------SDENISDL-------------------------- 370
                                           :.|::|||                          
Mouse   418 GSLVFTSEQAQLATSESLSLLSSASSQTQLATGESLSDLPSTSEQTVPECTIHFHGFLTNDSIIP 482

  Fly   371 ----------DDLKS--------------------ALQHHRESIIEPQY---------------- 389
                      ||..|                    .||..:..:.|..:                
Mouse   483 IKIHSRSDACDDEDSEESLSSEESHGHGSSHTGRLKLQISQRCVQEASWDLDKIEILQDDISITS 547

  Fly   390 -----DTFCHGHATAIY------------------------------------------------ 401
                 |..|.|.|.:|:                                                
Mouse   548 SWLGLDEQCKGDADSIWSLTDEELMACDQEKDSSSESEENCSPSPGCSFNEGFSFQLFKPNRVPK 612

  Fly   402 IDKFSRFFFPFSFFILNIVYW 422
            :|::|||.||.||.:.|:|||
Mouse   613 VDRWSRFLFPLSFGLFNVVYW 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HisCl1NP_731632.1 LGIC_ECD_HisCl 78..262 CDD:349793 54/186 (29%)
Cys-loop 182..196 CDD:349793 4/13 (31%)
LGIC_TM_anion 265..>351 CDD:349851 36/85 (42%)
TM1 helix 265..288 CDD:349851 10/22 (45%)
TM2 helix 292..316 CDD:349851 10/23 (43%)
TM3 helix 324..350 CDD:349851 13/25 (52%)
GabrqNP_065234.1 LGIC_ECD_GABAAR_theta 82..263 CDD:349804 54/185 (29%)
Cys-loop 183..197 CDD:349804 4/13 (31%)
LGIC_TM_GABAAR_theta 266..365 CDD:349858 36/98 (37%)
TM1 helix 266..289 CDD:349858 10/22 (45%)
TM2 helix 293..317 CDD:349858 10/23 (43%)
TM3 helix 325..351 CDD:349858 13/25 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..515 3/23 (13%)
LGIC_TM <604..636 CDD:476813 12/30 (40%)
TM4 helix 612..633 CDD:349858 10/20 (50%)

Return to query results.
Submit another query.