Protein Alignment HisCl1 and gabrd

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: XP_700099.5
• Gene: gabrd / 571422
• ZFINID: ZDB-GENE-081105-170
• Length: 459
• Species: Danio rerio
• Alignment Length: 420
• Identity: 132/420 - (31%)
• Similarity: 214/420 - (50%)
• Gaps: 55/420 - (13%)

  Fly    55 SLPDILPIPSKTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLP 119
            :|.|::    |.|.:|..|.:.|.|..|...:.|.|:|.|:|.:|.|...:||.|||||.||..
Zfish    44 NLDDLM----KGYARNFRPGIGGPPVNVAMAIEVASIDHISEANMEYTMTVFLRQSWRDDRLSY- 103

  Fly   120 ENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAM 184
             |.:.:...||..::..:|.||.|..|||...||::::.|..:.|..|..:||.|::|..::|.|
Zfish   104 -NHTNKTLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSSRITSTVACDM 167

  Fly   185 KFESYPHDTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTE-IELPQLDISN-NYTTDCTIEYST 247
            ....||.|.|.|.:.:||..::.||:|:.|:.:..|:...: :||.|..|:: .:.|:.....|.
Zfish   168 DLTKYPMDEQECMLDLESYGYSSEDIVYHWSESQKLIHGLDKLELSQFTITDYRFVTEMMNFKSA 232

  Fly   248 GNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQ 312
            |.|..|::.|.|||..|.::..:|:||.|:|.|||:||||...|:||||:||:|::||:.|....
Zfish   233 GRFPRLSLRFQLRRNRGVYIIQSYMPSILLVAMSWVSFWISQSAVPARVSLGITTVLTMTTLMVS 297

  Fly   313 SQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDENI-SDLDDLKSA 376
            ::.|||..|.:||:||:...|.||||.:|:|:|..:........:..|..:::|. |.:.:.|.|
Zfish   298 ARSSLPRASAIKALDVYFWICYVFVFAALIEYAFAHYNADYSKKEKAKVKTNKNAESMVKNGKQA 362

  Fly   377 L---------------------QHHRES-----IIEPQYDTFCHGHAT----------------- 398
            :                     :.||.|     ..:|..:|......:
Zfish   363 MVLFSLSVAGMNQGLLISNRQSRSHRASDAAAAAADPHEETETRSATSRRAQKESSEEKKCCKCK 427

  Fly   399 ---AIYIDKFSRFFFPFSFFILNIVYWTTF 425
               |..||.::|..|||:|.::|::||..:
Zfish   428 PIDADTIDIYARAVFPFTFAVVNVIYWVAY 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	63/185 (34%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	39/85 (46%)
		TM1 helix	265..288	CDD:349851	11/22 (50%)
		TM2 helix	292..316	CDD:349851	10/23 (43%)
		TM3 helix	324..350	CDD:349851	12/25 (48%)
gabrd	XP_700099.5	LIC	45..457	CDD:455710	132/417 (32%)
		LGIC_ECD	64..247	CDD:475126	63/184 (34%)