Protein Alignment HisCl1 and gabrr1

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001020724.1
• Gene: gabrr1 / 568984
• ZFINID: ZDB-GENE-040724-212
• Length: 466
• Species: Danio rerio
• Alignment Length: 463
• Identity: 146/463 - (31%)
• Similarity: 220/463 - (47%)
• Gaps: 54/463 - (11%)

  Fly    13 CLIALAIYLHALEQSIQHCHCVHGYRNNTESAELVSHYESSLSL---PDILPIP-SKT------- 66
            |.:..|.:|  ...::|.|......|..|. ||...|...|..|   ||:...| :|:
Zfish     6 CFLLCACFL--CTGALQSCSKSRSKRETTR-AERDLHKPGSTLLMRSPDVTKAPVTKSEQLLKLD 67

  Fly    67 -YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILD 130
             :|....|...|....|...|.:.|||:|:|..|.:...::|...|:|.||..|.| :.|....|
Zfish    68 DHDFTMRPGFGGPAIPVGVDVQLESLDTISEVDMDFTMTLYLRHYWKDARLSFPSN-TNQSMTFD 131

  Fly   131 VDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQI 195
            ...:..||.||.||.::|:...|:.:..|..|.::.|..:||..::|:...|.|....:|.|||.
Zfish   132 GRLVKKIWVPDIFFVHSKRSFIHDTTTENVMLRVHPDGKVLYSLRVTVTSMCNMDLSHFPLDTQT 196

  Fly   196 CSMMIESLSHTVEDLVFIWNM-TDPLVVNTEIELPQLDISNNYTTDCTIEY-STGNFTCLAIVFN 258
            ||:.|||.::|.:||:..|.. ...|..:.:|.|.|..|...:||.....| |||.:..|.|.|.
Zfish   197 CSLEIESYAYTDDDLMLYWKRGNKSLQTDDKISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFT 261

  Fly   259 LRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYV 323
            |||.:.:.|..||.|:.|:|::||:||||...|:||||.||:|::||::|..|....|:|.|||:
Zfish   262 LRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYI 326

  Fly   324 KAIDVWMSSCSVFVFLSLMEFAVVN----------------------NFMGPVATKAMKGYSDEN 366
            ||:|:::....||||||::|:|.||                      ....|........||:.:
Zfish   327 KAVDIYLWVSFVFVFLSVIEYAAVNYLSTLQERKERSQNSRQLPCTCGMTHPGQMMMSSSYSEMD 391

  Fly   367 --------ISDLDDLKSA--LQH----HRESIIEPQYDTFCHGHATAIYIDKFSRFFFPFSFFIL 417
                    :|:|.|.|..  |.|    :.:....|...|....:.....|||:||..||.::.:.
Zfish   392 MMTTGNYGMSELSDTKQEQFLVHLVMDNEQGAQRPAVTTSSTLNIDTHAIDKYSRVIFPGAYTLF 456

  Fly   418 NIVYWTTF 425
            ||:||:.:
Zfish   457 NIIYWSIY 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	62/185 (34%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	42/107 (39%)
		TM1 helix	265..288	CDD:349851	11/22 (50%)
		TM2 helix	292..316	CDD:349851	11/23 (48%)
		TM3 helix	324..350	CDD:349851	13/47 (28%)
gabrr1	NP_001020724.1	LIC	44..464	CDD:455710	135/420 (32%)
		LGIC_ECD	81..266	CDD:475126	63/185 (34%)