Protein Alignment HisCl1 and gabrp

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: XP_005173350.2
• Gene: gabrp / 566633
• ZFINID: ZDB-GENE-081028-62
• Length: 464
• Species: Danio rerio
• Alignment Length: 466
• Identity: 131/466 - (28%)
• Similarity: 219/466 - (46%)
• Gaps: 70/466 - (15%)

  Fly    21 LHALEQSIQHCHCV------------------HGYRNNTESAELVSHYESSLSLPDILPIPSKTY 67
            ||:.:.|..|.|.:                  .|:..|.     ...:..|...|.|..: .|.|
Zfish     7 LHSYQSSGLHYHRMLLNLLFWTSLFLLITNGERGFYGNQ-----YGEWNDSQLQPTIQKL-MKGY 65

  Fly    68 DKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVD 132
            ::...|.....|..:...:.:.|:|:|:|.:|.|...|||.|.|||.||..|.|.|..   ||..
Zfish    66 NRYLRPNFNEGPVEIGMSLDIASIDAISEINMDYTATIFLRQRWRDSRLIFPGNESLS---LDGR 127

  Fly   133 WLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICS 197
            .:..:|.||.|..::|:...|::::.|..:.::.:.|:||..::|..::|.|....||.|.|.|:
Zfish   128 LVSLLWIPDTFIPDSKRSFLHDVTVENRLIRIFSNGTVLYALRITATIACNMDLTKYPMDRQECT 192

  Fly   198 MMIESLSHTVEDLVFIWNMTDPLVVNTE-IELPQLDISNNYTTDCTIEYSTGNFTCLAIVFNLRR 261
            :.:||..:.:||:||.|...:..|...: :.|.|..:.:.||:.....|.||.:..|.:.|.|||
Zfish   193 LQLESWGYNLEDVVFYWTRGNDSVKGLDTLRLAQYSVESYYTSVTKAVYETGLYPKLILHFALRR 257

  Fly   262 RLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVS-YVKA 325
            .:.:.:..||:||.|:||:||:||||...::|||..:|||::||:.|....::.|||..: ::||
Zfish   258 NVLFFILETYVPSTLLVVLSWVSFWISQSSVPARTCIGVTTVLTMTTLMMGARTSLPNANCFIKA 322

  Fly   326 IDVWMSSCSVFVFLSLMEFA------VVNNFMGPVATKAMKGYSDEN-----ISDLDDLK----- 374
            |||::..|..|:|.:|:|:|      :.:..:..|..:.:|.:.:.|     :|.:...|
Zfish   323 IDVYLGICFTFIFGALLEYACAHFCTMQHQTIIDVQRELLKEFEESNGTTHLVSSMSPRKMKTED 387

  Fly   375 SALQHHRE--------SIIEPQYDTFCHGHATAIY----------------IDKFSRFFFPFSFF 415
            |..|...|        ..:|...:..| |..|...                ||:.:|..||.:|.
Zfish   388 STKQEKPEQTVTCEENEAVEQTKEKGC-GLTTVKQMSRRAASMMSVENPHNIDRHARILFPMAFL 451

  Fly   416 ILNIVYWTTFL 426
            ::||.||..:|
Zfish   452 LINIFYWLYYL 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	58/184 (32%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	36/92 (39%)
		TM1 helix	265..288	CDD:349851	12/22 (55%)
		TM2 helix	292..316	CDD:349851	9/23 (39%)
		TM3 helix	324..350	CDD:349851	11/31 (35%)
gabrp	XP_005173350.2	None