Protein Alignment HisCl1 and LOC562831

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: XP_009305888.1
• Gene: LOC562831 / 562831
• -ID: -
• Length: 451
• Species: Danio rerio
• Alignment Length: 446
• Identity: 130/446 - (29%)
• Similarity: 216/446 - (48%)
• Gaps: 75/446 - (16%)

  Fly    42 ESAELVSHYESSLSLPDILPIPSKTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIF 106
            |::.|.:..:....||..:....|.|:|...|.....|..|...:.:.|:|:|:|.:|.|...||
Zfish    18 ENSLLNAEVKEGEILPPTIQKLMKGYNKYLRPFFDNGPVTVGMSLDIASIDTISEINMDYTATIF 82

  Fly   107 LAQSWRDPRLRLPENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLL 171
            |.|.|.|.||....|.|..   ||...:..:|.||.|..::||...|::::.|..:.::.:.|:|
Zfish    83 LRQRWTDERLLFEGNKSLS---LDGRLVELLWVPDTFIVDSKKSFLHDITVENRLIRIFPNGTVL 144

  Fly   172 YMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTE-IELPQLDISN 235
            |..::|..::|.|....||.|.|.|::.:||..:.|.|::|.|...:..|...: :.|.|..:.:
Zfish   145 YALRITTTVACNMDLTKYPMDKQTCTLQLESWGYNVNDVMFYWARGNESVSGLDTLRLAQYTVED 209

  Fly   236 NYTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGV 300
            :||:.....|.|||:..|...|.|:|.:.|.:..||:||:|:||:||:||||...::|||:.:||
Zfish   210 HYTSASEAVYETGNYPKLIFHFELKRSILYFILETYVPSSLLVVLSWVSFWISQSSVPARICIGV 274

  Fly   301 TSLLTLATQNTQSQQSLPPVS-YVKAIDVWMSSCSVFVFLSLMEFAVV----------NNFMGPV 354
            |::||:.|....::.|||..: ::|||||::..|..|:|.:|:|:||.          ||.:
Zfish   275 TTVLTMTTLMMGARTSLPNANCFIKAIDVYLGICFSFIFGALIEYAVAHFCTLHHPDCNNAL--- 336

  Fly   355 ATKAMKGYSDENISDLDDL----------KSALQHHRESIIEP---------------------- 387
                |.|:...::.|.::.          .|.|:..:::..:|
Zfish   337 ----MYGHHHHHMHDCEEEMNGMLTTISDSSRLKRRKDTAADPPKASDGEPEPVPSGPETPAEPV 397

  Fly   388 --------------QYDTFCH---GHATAIYIDKFSRFFFPFSFFILNIVYWTTFL 426
                          :....||   .|    |||.:||..||.||.|:|::|||.:|
Zfish   398 SRCAKSITLLRKILRSVNCCHVKNPH----YIDNYSRLTFPLSFIIVNLLYWTYYL 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	57/184 (31%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	40/96 (42%)
		TM1 helix	265..288	CDD:349851	13/22 (59%)
		TM2 helix	292..316	CDD:349851	9/23 (39%)
		TM3 helix	324..350	CDD:349851	13/35 (37%)
LOC562831	XP_009305888.1	LIC	7..448	CDD:455710	129/443 (29%)
		LGIC_ECD_GABAAR_pi	55..236	CDD:349805	57/183 (31%)
		Cys-loop	154..169	CDD:349805	6/14 (43%)