Protein Alignment HisCl1 and GABRQ

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_061028.3
• Gene: GABRQ / 55879
• HGNCID: 14454
• Length: 632
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 131/606 - (21%)
• Similarity: 216/606 - (35%)
• Gaps: 243/606 - (40%)

  Fly    49 HYESSLSLPD-------------------ILPIPSKTYDKNRAPKLLGQPTVVYFHVTVLSLDSI 94
            |:|.|.::|:                   ||......||....|...|.|..|...:.|.|::.|
Human    33 HFEFSSAVPEVVLNLFNCKNCANEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQI 97

  Fly    95 NEESMTYVTDIFLAQSWRDPRLRLPE---NMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMS 156
            :|.:|.|...:|..|:|:|.||...|   |::..||:.:     .:|.|||:|.|:|....|:::
Human    98 SEMNMDYTITMFFHQTWKDSRLAYYETTLNLTLDYRMHE-----KLWVPDCYFLNSKDAFVHDVT 157

  Fly   157 IPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIW------- 214
            :.|....|:.|.|:.|..:||...:|::....:|.|.|.|::::||..:||||::..|
Human   158 VENRVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAI 222

  Fly   215 NMTDPLVVNTEIELPQLDISNNYTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVV 279
            :||:      |:.:||........|...:.:.||::..|.:.|.::|.:..:|...|.|:.|..:
Human   223 HMTE------ELHIPQFTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTI 281

  Fly   280 MSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEF 344
            .||||||:..::..||||:|:||:|.|.|.::..:..||.:|.:||||:::..|..||||||:|:
Human   282 TSWISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEY 346

  Fly   345 AVVNNF----------------------------------------------------MGPVATK 357
            ..:|..                                                    ..|:|:.
Human   347 VYINYLFYSRGPRRQPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASP 411

  Fly   358 AMKG-----------------------------YSDENISDL--------------------DDL 373
            ...|                             .:.|::|||                    ||.
Human   412 ESLGSLTSTSEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDS 476

  Fly   374 ----------------------------------------KSALQHHRESIIEPQYD-------- 390
                                                    |..|.|..:.:.|..:|
Human   477 IIPTEIRNRVEAHGHGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDKS 541

  Fly   391 -----------------------------------------------TFCHGHATAIY------- 401
                                                           :|..|.:..::
Human   542 DCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVPK 606

  Fly   402 IDKFSRFFFPFSFFILNIVYW 422
            :||:|||.||.:|.:.|||||
Human   607 VDKWSRFLFPLAFGLFNIVYW 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	59/204 (29%)
		Neur_chan_memb	270..>350	CDD:280999	35/79 (44%)
GABRQ	NP_061028.3	Neur_chan_LBD	60..>353	CDD:332142	98/303 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..458		5/47 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..523		2/31 (6%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810