DRSC/TRiP Functional Genomics Resources

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Protein Alignment HisCl1 and gabra4

DIOPT Version :10

Sequence 1:NP_731632.1 Gene:HisCl1 / 41426 FlyBaseID:FBgn0037950 Length:426 Species:Drosophila melanogaster
Sequence 2:NP_001017822.1 Gene:gabra4 / 550520 ZFINID:ZDB-GENE-050417-360 Length:557 Species:Danio rerio


Alignment Length:493 Identity:121/493 - (24%)
Similarity:195/493 - (39%) Gaps:137/493 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131
            ||....|...|..|.|...:.|.|...:::..|.|..|:|..|:|.|.|||. |...|..|:.::
Zfish    59 YDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWVDRRLRY-EGPVEILRLNNL 122

  Fly   132 DWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQIC 196
             .:..:|.||.||:|.|:...|.|:.||....:..:.|:||..:||:...|.|:..::|.|...|
Zfish   123 -MVTKVWTPDTFFRNGKRSVAHNMTAPNRLFRIMKNGTILYTMRLTISAECPMRLVNFPMDGHSC 186

  Fly   197 SMMIESLSHTVEDLVFIWNMTDPLVVNTEIE---LPQLDISNNYTTDCTIEYSTGNFTCLAIVFN 258
            .:...|.::...::::.|.......|....|   |.|.|:.....:..|::..||.:..:.:.|:
Zfish   187 PLKFGSYAYPKTEMIYTWTKGPQHSVEVPPESSSLVQYDLIGQTVSSETVKSITGEYVVMTVYFH 251

  Fly   259 LRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYV 323
            |:|::||.:..||||..:.|::|.:||||..|::|||...|:|::||:.|.:..::.|||.|||.
Zfish   252 LKRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA 316

  Fly   324 KAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYS------------------------- 363
            .|:|.:::.|..|||.:|:|||.||.|....|.:|.:..:                         
Zfish   317 TAMDWFIAVCFAFVFSALIEFAAVNYFTNAQAERAKRKQAKAAAAASVKSSTGKNKDTEEVLQQN 381

  Fly   364 -----------DENISDLDDLK------------------------------------------- 374
                       :.||....:.|                                           
Zfish   382 SDTNGNLRKRVNSNIQPQAESKKTQRTEASSKSGASSSKPTLTSQSSSTSEGTSSFSSQSRLSPS 446

  Fly   375 ----------------------------------------SALQHH-----------RESIIEPQ 388
                                                    ||..||           :|:..:||
Zfish   447 SASQSNAAASSSSASKTTPPAPPSTPTVPDKPSPGTTPAGSAPLHHLLGPKLENIKKKEAKAQPQ 511

  Fly   389 YDTFCHGHATAIYIDKFSRFFFPFSFFILNIVYWTTFL 426
            ......|.|:.  ||:::|..||.||...|:|||..:|
Zfish   512 PAAPATGGASK--IDEYARILFPVSFGAFNMVYWVVYL 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HisCl1NP_731632.1 LGIC_ECD_HisCl 78..262 CDD:349793 50/186 (27%)
Cys-loop 182..196 CDD:349793 4/13 (31%)
LGIC_TM_anion 265..>351 CDD:349851 38/85 (45%)
TM1 helix 265..288 CDD:349851 10/22 (45%)
TM2 helix 292..316 CDD:349851 8/23 (35%)
TM3 helix 324..350 CDD:349851 12/25 (48%)
gabra4NP_001017822.1 LGIC_ECD_GABAAR_A4 57..255 CDD:349838 54/197 (27%)
Cys-loop 172..186 CDD:349838 4/13 (31%)
LGIC_TM_GABAAR_alpha 258..347 CDD:349854 39/88 (44%)
TM1 helix 258..281 CDD:349854 10/22 (45%)
Neur_chan_memb 263..543 CDD:460753 61/281 (22%)
TM2 helix 285..309 CDD:349854 8/23 (35%)
TM3 helix 317..343 CDD:349854 12/25 (48%)

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