Protein Alignment HisCl1 and nAChRalpha1

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 344
• Identity: 82/344 - (23%)
• Similarity: 142/344 - (41%)
• Gaps: 62/344 - (18%)

  Fly    49 HYES-SLSLPDILPIPSKTYDK-----NRAPKLLGQPT---VVYFHVTVLSLDSINEESMTYVTD 104
            |:.: .|:.||    ..:.||.     ||..:.:|..:   .|...:.:..|..:|.::....|:
  Fly    14 HFATGGLANPD----AKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTN 74

  Fly   105 IFLAQSWRDPRLRL-PENMSEQYRILDVDWLH----SIWRPD-CFFKNAK---KVTFHEMSIPNH 160
            :::.|.|.|.:|:. |::..      .||.||    .||.|| ..:.||.   :||....:|
  Fly    75 VWVEQEWNDYKLKWNPDDYG------GVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAI--- 130

  Fly   161 YLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHT--VEDLVFIWNMTDPLVVN 223
               |:|...:::.........|.:..|.:|.|.|.|.|...|.::.  :.||..:....|...:.
  Fly   131 ---LHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIE 192

  Fly   224 TEIELPQLDIS-------------NNYTTDCTIEYSTGNFTCLAIVFN--LRRRLGYHLFHTYIP 273
            ..|:|....||             ..:.:.|...|       |.||||  |||:..::..:..||
  Fly   193 VGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPY-------LDIVFNLTLRRKTLFYTVNLIIP 250

  Fly   274 SALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSY-VKAIDVWMSSCSVFV 337
            ...|..:|.:.|:: |.....:::|.::.||:|........:.:||.|. |..:..::....:.|
  Fly   251 CVGISFLSVLVFYL-PSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLV 314

  Fly   338 FLS-LMEFAVVN-NFMGPV 354
            .|| ::..||:| ||..||
  Fly   315 TLSVVVTIAVLNVNFRSPV 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	53/228 (23%)
		Neur_chan_memb	270..>350	CDD:280999	20/82 (24%)
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	54/233 (23%)
		LIC	27..530	CDD:273305	78/327 (24%)
		Neur_chan_memb	247..530	CDD:280999	24/88 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100