DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HisCl1 and srsx-31

DIOPT Version :9

Sequence 1:	NP_731632.1	Gene:	HisCl1 / 41426	FlyBaseID:	FBgn0037950	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001023767.1	Gene:	srsx-31 / 3565162	WormBaseID:	WBGene00008552	Length:	308	Species:	Caenorhabditis elegans

Alignment Length:	168	Identity:	37/168 - (22%)
Similarity:	71/168 - (42%)	Gaps:	34/168 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 IEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWI----------------KPEA 291
            |:|:| ...|:|.:...|:..||..:.:.|.:..||::...::::                |..|
Worm   147 IDYNT-QIICMAPLALPRQAFGYFTYSSNIINVKIVIVYAYTYFVLRGYKERDANRMRYVFKSIA 210

  Fly   292 IPARVTL-GVTSLL---TLATQNTQSQQSLPPVSYVKAIDVWMS-SCSVFVFLSL-MEF-AVVNN 349
            :...|.| |.|::.   |:|....:.:.:...:|......|.:| |.:|.||.:: .|: :.:..
Worm   211 LTVIVVLIGWTTVTIGNTIALGVIEDRHTSEIISIHAGFGVNISCSINVIVFYAINSEYRSAIRR 275

  Fly   350 FMGPVATKAMKGYSDENISDLDDLKSALQHHRESIIEP 387
            ..|      ||.:|    ||:.....::...|.||:.|
Worm   276 LFG------MKIHS----SDVSKSDPSVITKRISIVSP 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	6/18 (33%)
HisCl1	NP_731632.1	Neur_chan_memb	270..>350	CDD:280999	19/102 (19%)
srsx-31	NP_001023767.1	TM helix 1	11..36	CDD:341315
		7TM_GPCR_Srsx	19..277	CDD:255903	27/130 (21%)
		TM helix 2	43..67	CDD:341315
		TM helix 3	79..109	CDD:341315
		TM helix 4	122..140	CDD:341315
		TM helix 5	165..190	CDD:341315	5/24 (21%)
		TM helix 6	201..230	CDD:341315	7/28 (25%)
		TM helix 7	241..266	CDD:341315	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900