Protein Alignment HisCl1 and gabrb2a

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001019558.2
• Gene: gabrb2a / 336252
• ZFINID: ZDB-GENE-030131-8196
• Length: 519
• Species: Danio rerio
• Alignment Length: 501
• Identity: 150/501 - (29%)
• Similarity: 223/501 - (44%)
• Gaps: 134/501 - (26%)

  Fly    53 SLSLPDILPIPSKT-------YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQS 110
            |:..|..:|:...|       ||....|...|.|..|..::.:.|:|.::|.:|.|...::..|:
Zfish    25 SIRDPSNMPVVKDTVDRLMKGYDIRLRPDFGGAPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQA 89

  Fly   111 WRDPRL---RLPENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLY 172
            |||.||   .:|.|::...|:.|     .:|.||.:|.|.||...|.:::.|..:.|:.|.|:||
Zfish    90 WRDKRLSYSEIPLNLTLDNRVAD-----QLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLY 149

  Fly   173 MSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTE-IELPQLDISNN 236
            ..::|...:|.|....||.|.|.|::.|||..:|.:|:.|.|...|..|...| |||||..|.:.
Zfish   150 GLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDGAVSGVERIELPQFSIVDY 214

  Fly   237 YTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVT 301
            ......:.:|||::..|::.|.|:|.:||.:..||:||.||.::||:||||..:|..|||.||:|
Zfish   215 KLISKNVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGIT 279

  Fly   302 SLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFM---GP-----VATKA 358
            ::||:.|.||..:::||.:.||||||:::..|.|||||:|:|:|.||...   ||     .|.||
Zfish   280 TVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKAAEKA 344

  Fly   359 ------------------------------MK---------------------GYSDENIS-DLD 371
                                          ||                     |..|:.:. ..|
Zfish   345 ATANNEKLRPDPNKWLVGSVVQRDDALYARMKQREIDGYDSMWDPIFAEDAALGLGDQRLKMTPD 409

  Fly   372 DLK-------------------------------SALQHHRESIIEPQY-DTFCHGHAT------ 398
            |::                               |.||:.|.::....| .:....|||
Zfish   410 DIRLTTVEMKNEMGPSDLSRGLGDPRSTMLAYDSSTLQYRRAAMARQNYGHSALERHATQKKSRL 474

  Fly   399 ----------------AIYIDKFSRFFFP--FSFFILNIVYWTTFL 426
                            ...|||:||..||  ||||  |||||..::
Zfish   475 RRRASQLKVNIPDLSDVNSIDKWSRMIFPTLFSFF--NIVYWLYYV 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	61/187 (33%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	44/85 (52%)
		TM1 helix	265..288	CDD:349851	12/22 (55%)
		TM2 helix	292..316	CDD:349851	11/23 (48%)
		TM3 helix	324..350	CDD:349851	15/25 (60%)
gabrb2a	NP_001019558.2	LIC	7..517	CDD:273305	150/498 (30%)