Protein Alignment HisCl1 and Gabra6

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_068613.2
• Gene: Gabra6 / 29708
• RGDID: 61861
• Length: 453
• Species: Rattus norvegicus
• Alignment Length: 407
• Identity: 119/407 - (29%)
• Similarity: 188/407 - (46%)
• Gaps: 55/407 - (13%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRL--PENMSEQYRIL 129
            ||....|...|..|.|...:.|.|...:::..|.|..|:|..|:|.|.||:.  |..:.....::
  Rat    43 YDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFKGPAEILSLNNLM 107

  Fly   130 DVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194
                :..||.||.||:|.||...|.|:.||....|..:.|:||..:||:...|.|:..::|.|..
  Rat   108 ----VSKIWTPDTFFQNGKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRLVNFPMDGH 168

  Fly   195 ICSMMIESLSHTVEDLVFIWNMTDPLVVNTEIELP-------QLDISNNYTTDCTIEYSTGNFTC 252
            .|.:...|.::...::::.|. ..||.   .:|:|       |.|:.....:..||:.:||.:..
  Rat   169 ACPLKFGSYAYPKSEIIYTWK-KGPLY---SVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVI 229

  Fly   253 LAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSL 317
            :.:.|:|:|::||.:...|.|..:.|::|.:||||..|::|||...|:|::||:.|.:..::.||
  Rat   230 MTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSL 294

  Fly   318 PPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMG----------------PVATKAMKGYSDEN 366
            |.|||..|:|.:::.|..|||.:|:|||.||.|..                |||........:..
  Rat   295 PKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQKAERQAQTAAKPPVAKSKTTESLEAE 359

  Fly   367 ISDLDDLKSALQHHRESI---IEPQYDTFCHGHATAIY-------------------IDKFSRFF 409
            |....|.|..|:....|:   |.|..:.......|.|.                   ||::||..
  Rat   360 IVVHSDSKYHLKKRISSLTLPIVPSSEASKVLSRTPILPSTPVTPPLLLPAIGGTSKIDQYSRIL 424

  Fly   410 FPFSFFILNIVYWTTFL 426
            ||.:|...|:|||..:|
  Rat   425 FPVAFAGFNLVYWIVYL 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	52/192 (27%)
		Cys-loop	182..196	CDD:349793	4/13 (31%)
		LGIC_TM_anion	265..>351	CDD:349851	36/85 (42%)
		TM1 helix	265..288	CDD:349851	8/22 (36%)
		TM2 helix	292..316	CDD:349851	8/23 (35%)
		TM3 helix	324..350	CDD:349851	12/25 (48%)
Gabra6	NP_068613.2	LIC	34..440	CDD:455710	118/404 (29%)
		LGIC_ECD	42..239	CDD:475126	56/203 (28%)