Protein Alignment HisCl1 and Gabrr1

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_058987.3
• Gene: Gabrr1 / 29694
• RGDID: 61900
• Length: 480
• Species: Rattus norvegicus
• Alignment Length: 431
• Identity: 142/431 - (32%)
• Similarity: 211/431 - (48%)
• Gaps: 77/431 - (17%)

  Fly    61 PIPSKTYDKNRAP-----KLL-------------GQPTV-VYFHVTVLSLDSINEESMTYVTDIF 106
            ||..::.|..::|     :||             |.|.: |...|.|.|||||:|..|.:...::
  Rat    60 PILKRSSDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLY 124

  Fly   107 LAQSWRDPRLRLP--ENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKT 169
            |...|:|.||..|  .|:|..:   |...:..||.||.||.::|:...|:.:..|..|.:..|..
  Rat   125 LRHYWKDERLSFPSTNNLSMTF---DGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGK 186

  Fly   170 LLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNM-TDPLVVNTEIELPQLDI 233
            :||..::|:...|.|.|..:|.|||.||:.|||.::|.:||:..|.. .|.|..:..|.|.|..|
  Rat   187 VLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLI 251

  Fly   234 SNNYTTDCTIEY-STGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVT 297
            ...:||.....| |||.:..|.|.|.|||.:.:.|..||.|:.|:|::||:||||...|:||||.
  Rat   252 QEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVP 316

  Fly   298 LGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMK-- 360
            ||:|::||::|..|....|:|.|||:||:|:::....||||||::|:|.||........|..|
  Rat   317 LGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLR 381

  Fly   361 -------------------GYSDENISDL-----------DDLKSAL-----------QHHRESI 384
                               .|||..::||           |.:...|           :..|.|.
  Rat   382 EKISCTCGLPQPRGVMLDSSYSDGEVNDLGGYMPENGEKPDRMMVQLTLASERGSPQRKSQRGSY 446

  Fly   385 IEPQYDTFCHGHATAIYIDKFSRFFFPFSFFILNIVYWTTF 425
            :..:.:|    ||    |||:||..||.::.:.|::||:.|
  Rat   447 VSMRINT----HA----IDKYSRIIFPAAYILFNLIYWSIF 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	67/188 (36%)
		Cys-loop	182..196	CDD:349793	7/13 (54%)
		LGIC_TM_anion	265..>351	CDD:349851	42/85 (49%)
		TM1 helix	265..288	CDD:349851	11/22 (50%)
		TM2 helix	292..316	CDD:349851	11/23 (48%)
		TM3 helix	324..350	CDD:349851	13/25 (52%)
Gabrr1	NP_058987.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..67		2/6 (33%)
		LIC	76..479	CDD:455710	137/413 (33%)
		LGIC_ECD_GABAAR_rho	97..282	CDD:349806	67/187 (36%)
		Cys-loop	199..213	CDD:349806	7/13 (54%)