Protein Alignment HisCl1 and GLRA2

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001112357.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 160/448 - (35%)
• Similarity: 231/448 - (51%)
• Gaps: 51/448 - (11%)

  Fly    15 IALAIYLHALEQS-IQHCHCV-HGYRNNTESAELVSHYESSLSLPDIL-PIPSKT--YDKNRAPK 74
            |..|::...||.: .:...|. |..|:..:.::       :||..|.| .:..:|  ||....|.
Human     8 ILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQ-------TLSPSDFLDKLMGRTSGYDARIRPN 65

  Fly    75 LLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVD--WLHSI 137
            ..|.|..|..::.:.|..|:.|.:|.|..:|||.|.|.|.||...|...:.   ||:|  .|.||
Human    66 FKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDS---LDLDPSMLDSI 127

  Fly   138 WRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIES 202
            |:||.||.|.|...||:::..|..|.:..:..:||..:|||.|||.|..:::|.|.|.|:|.:||
Human   128 WKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLES 192

  Fly   203 LSHTVEDLVFIWNMTDPLVVNTEIELPQLDISNNYTTD-CTIEYSTGNFTCLAIVFNLRRRLGYH 266
            ..:|:.||:|.|....|:.|...:.|||..:....... ||..|:||.|||:.:.|:|.|::||:
Human   193 FGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYY 257

  Fly   267 LFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMS 331
            |...||||.|||::||:||||..:|.||||.||:|::||:.||::.|:.|||.||||||||:||:
Human   258 LIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMA 322

  Fly   332 SCSVFVFLSLMEFAVVN-------------------NFMGPVATKA---MKGYSDENISDLDDLK 374
            .|.:|||.:|:|:|.||                   |....|..::   ..||...:...:.|..
Human   323 VCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGT 387

  Fly   375 SALQHHRESIIEPQYDTFCHGHA-------TAIYIDKFSRFFFPFSFFILNIVYWTTF 425
            :........:.:|..|    |.|       .|..||..||..||.:|.|.||.||.|:
Human   388 AVKATPANPLPQPPKD----GDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	73/197 (37%)
		Neur_chan_memb	270..>350	CDD:280999	48/98 (49%)
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	150/401 (37%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930