Protein Alignment HisCl1 and GABRR2

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_002034.3
• Gene: GABRR2 / 2570
• HGNCID: 4091
• Length: 465
• Species: Homo sapiens
• Alignment Length: 436
• Identity: 140/436 - (32%)
• Similarity: 215/436 - (49%)
• Gaps: 75/436 - (17%)

  Fly    60 LPIPSKTYDKN---------RAPKLL-------------GQPTV-VYFHVTVLSLDSINEESMTY 101
            :|.||..|.||         :..:||             |.|.: |...|.|.|||||:|..|.:
Human    34 MPKPSHLYKKNLDVTKIRKGKPQQLLRVDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDF 98

  Fly   102 VTDIFLAQSWRDPRLRLPENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYH 166
            ...::|...|:|.||.. .:.|.:....|...:..||.||.||.::|:...|:.:..|..|.::.
Human    99 TMTLYLRHYWKDERLAF-SSASNKSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFP 162

  Fly   167 DKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIW-NMTDPLVVNTEIELPQ 230
            |..:||..::|:...|.|.|..:|.|:|.||:.:||.::|.|||:..| |..:.|..:.:|.|.|
Human   163 DGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQ 227

  Fly   231 LDISNNYTTDCTIEY-STGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPA 294
            ..|...:||.....| |||.:..|.|.|.|||.:.:.|..||.|:.|:|::||:||||...|:||
Human   228 FLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPA 292

  Fly   295 RVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNN---------- 349
            ||:||:|::||:.|..|....|:|.||||||:|:::....||||||::|:|.||.
Human   293 RVSLGITTVLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKER 357

  Fly   350 --------FMGPVATKAM--------------KGYSDENISDLDDLKSALQHH-----------R 381
                    ..|.:.:|.|              .||...:|...::.:..:..|           :
Human   358 KLREKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAARK 422

  Fly   382 ESIIEPQ--YDTFCHGHATAIYIDKFSRFFFPFSFFILNIVYWTTF 425
            :.:::.|  :..|.:.||    |||:||..||.|:...|::||:.|
Human   423 KGLLKGQTGFRIFQNTHA----IDKYSRLIFPASYIFFNLIYWSVF 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	70/219 (32%)
		Neur_chan_memb	270..>350	CDD:280999	42/97 (43%)
GABRR2	NP_002034.3	Neur_chan_LBD	51..464	CDD:332142	133/417 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810