Protein Alignment HisCl1 and GABRB3

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_000805.1
• Gene: GABRB3 / 2562
• HGNCID: 4083
• Length: 473
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 136/432 - (31%)
• Similarity: 215/432 - (49%)
• Gaps: 75/432 - (17%)

  Fly    65 KTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLR---LPENMSEQY 126
            |.||....|...|.|..|..::.:.|:|.::|.:|.|...::..|.|||.||.   :|.|::...
Human    46 KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDN 110

  Fly   127 RILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPH 191
            |:.|     .:|.||.:|.|.||...|.:::.|..:.|:.|.|:||..::|...:|.|....||.
Human   111 RVAD-----QLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPL 170

  Fly   192 DTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTE-IELPQLDISNNYTTDCTIEYSTGNFTCLAI 255
            |.|.|::.|||..:|.:|:.|.|...|..|...| |||||..|..:......:.::||.:..|::
Human   171 DEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSL 235

  Fly   256 VFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPV 320
            .|.|:|.:||.:..||:||.||.::||:||||..:|..|||.||:|::||:.|.||..:::||.:
Human   236 SFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300

  Fly   321 SYVKAIDVWMSSCSVFVFLSLMEFAVVNNFM---GP-----VATKAMKGYSDENISD-------- 369
            .||||||:::..|.|||||:|:|:|.||...   ||     :|.|..|..:|.:.|:
Human   301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHG 365

  Fly   370 -------------------LDDLK--------SALQHHRESIIE------------PQYDTFCHG 395
                               :.|.:        |.:|:.::|:..            |...|....
Human   366 NILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRR 430

  Fly   396 HATAI-----------YIDKFSRFFFPFSFFILNIVYWTTFL 426
            .::.:           .||::||..|||:|.:.|:|||..::
Human   431 RSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYV 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	60/187 (32%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	44/85 (52%)
		TM1 helix	265..288	CDD:349851	12/22 (55%)
		TM2 helix	292..316	CDD:349851	11/23 (48%)
		TM3 helix	324..350	CDD:349851	15/25 (60%)
GABRB3	NP_000805.1	LIC	10..471	CDD:273305	136/429 (32%)