DRSC/TRiP Functional Genomics Resources

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Protein Alignment HisCl1 and GABRB3

DIOPT Version :9

Sequence 1:NP_731632.1 Gene:HisCl1 / 41426 FlyBaseID:FBgn0037950 Length:426 Species:Drosophila melanogaster
Sequence 2:NP_000805.1 Gene:GABRB3 / 2562 HGNCID:4083 Length:473 Species:Homo sapiens


Alignment Length:432 Identity:136/432 - (31%)
Similarity:215/432 - (49%) Gaps:75/432 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 KTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLR---LPENMSEQY 126
            |.||....|...|.|..|..::.:.|:|.::|.:|.|...::..|.|||.||.   :|.|::...
Human    46 KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDN 110

  Fly   127 RILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPH 191
            |:.|     .:|.||.:|.|.||...|.:::.|..:.|:.|.|:||..::|...:|.|....||.
Human   111 RVAD-----QLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPL 170

  Fly   192 DTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTE-IELPQLDISNNYTTDCTIEYSTGNFTCLAI 255
            |.|.|::.|||..:|.:|:.|.|...|..|...| |||||..|..:......:.::||.:..|::
Human   171 DEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSL 235

  Fly   256 VFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPV 320
            .|.|:|.:||.:..||:||.||.::||:||||..:|..|||.||:|::||:.|.||..:::||.:
Human   236 SFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300

  Fly   321 SYVKAIDVWMSSCSVFVFLSLMEFAVVNNFM---GP-----VATKAMKGYSDENISD-------- 369
            .||||||:::..|.|||||:|:|:|.||...   ||     :|.|..|..:|.:.|:        
Human   301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHG 365

  Fly   370 -------------------LDDLK--------SALQHHRESIIE------------PQYDTFCHG 395
                               :.|.:        |.:|:.::|:..            |...|....
Human   366 NILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRR 430

  Fly   396 HATAI-----------YIDKFSRFFFPFSFFILNIVYWTTFL 426
            .::.:           .||::||..|||:|.:.|:|||..::
Human   431 RSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYV 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HisCl1NP_731632.1 Neur_chan_LBD 67..262 CDD:280998 64/198 (32%)
Neur_chan_memb 270..>350 CDD:280999 43/79 (54%)
GABRB3NP_000805.1 LIC 10..471 CDD:273305 136/429 (32%)
Benzamidine binding, agonist. /evidence=ECO:0000269|PubMed:24909990 120..122 1/1 (100%)
Benzamidine binding, agonist. /evidence=ECO:0000269|PubMed:24909990, ECO:0007744|PDB:4COF 180..182 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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