Protein Alignment HisCl1 and GABRB1

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_000803.2
• Gene: GABRB1 / 2560
• HGNCID: 4081
• Length: 474
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 136/433 - (31%)
• Similarity: 215/433 - (49%)
• Gaps: 76/433 - (17%)

  Fly    65 KTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLR---LPENMSEQY 126
            |.||....|...|.|..|...:.|.|:|.::|.:|.|...::..|||:|.||.   :|.|::...
Human    46 KGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDN 110

  Fly   127 RILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPH 191
            |:.|     .:|.||.:|.|.||...|.:::.|..:.|:.|.|:||..::|...:|.|....||.
Human   111 RVAD-----QLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPL 170

  Fly   192 DTQICSMMIESLSHTVEDLVFIWNMTDPLVVN-TEIELPQLDISNNYTTDCTIEYSTGNFTCLAI 255
            |.|.|::.|||..:|.:|:.|.||..:..|.. .:|||||..|.:.......:|::||.:..|::
Human   171 DEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSL 235

  Fly   256 VFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPV 320
            .|.|:|.:||.:..||:||.||.::||:||||..:|..|||.||:|::||:.|.:|..:::||.:
Human   236 SFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI 300

  Fly   321 SYVKAIDVWMSSCSVFVFLSLMEFAVVNN-FMGPVATKAMKGYSDENISDLDDLK---------- 374
            .||||||:::..|.|||||:|:|:|.||. |.|....|......|::.::.:.|:
Human   301 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHG 365

  Fly   375 ----SALQHHRE--------SIIEPQYDTFCHGHATAIY-------------------------- 401
                |.|:...|        |:.:|:...:.:..|:..|
Human   366 NILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIR 430

  Fly   402 ------------------IDKFSRFFFPFSFFILNIVYWTTFL 426
                              |||:||.|||.:|.:.|:|||..::
Human   431 RRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYV 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	65/198 (33%)
		Neur_chan_memb	270..>350	CDD:280999	42/80 (53%)
GABRB1	NP_000803.2	LIC	9..472	CDD:273305	136/430 (32%)
		Agonist binding. /evidence=ECO:0000250	120..122		1/1 (100%)
		Agonist binding. /evidence=ECO:0000250	180..182		1/1 (100%)
		Allosteric effector binding. /evidence=ECO:0000250	290..311		9/20 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810