Protein Alignment HisCl1 and GABRA6

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_000802.2
• Gene: GABRA6 / 2559
• HGNCID: 4080
• Length: 453
• Species: Homo sapiens
• Alignment Length: 411
• Identity: 115/411 - (27%)
• Similarity: 187/411 - (45%)
• Gaps: 63/411 - (15%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRL--PENMSEQYRIL 129
            ||....|...|..|.|...:.|.|...:::..|.|..|:|..|:|.|.||:.  |..:.....::
Human    43 YDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLM 107

  Fly   130 DVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194
                :..||.||.||:|.||...|.|:.||....:..:.|:||..:||:...|.|:..::|.|..
Human   108 ----VSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGH 168

  Fly   195 ICSMMIESLSHTVEDLVFIWNMTDPLVVNTEIELP-------QLDISNNYTTDCTIEYSTGNFTC 252
            .|.:...|.::...::::.|. ..||.   .:|:|       |.|:.....:..||:.:||.:..
Human   169 ACPLKFGSYAYPKSEIIYTWK-KGPLY---SVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVI 229

  Fly   253 LAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSL 317
            :.:.|:|:|::||.:...|.|..:.|::|.:||||..|::|||...|:|::||:.|.:..::.||
Human   230 MTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSL 294

  Fly   318 PPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMG---------------PVAT--KAMKGYSDE 365
            |.|||..|:|.:::.|..|||.:|:|||.||.|..               |..|  ||.:....|
Human   295 PKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAE 359

  Fly   366 NISDLDDLKSALQHHRESIIEPQYDTFCHGHATAIY-------------------------IDKF 405
            .:...|    :..|.::.|............|..:.                         ||::
Human   360 IVLHPD----SKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY 420

  Fly   406 SRFFFPFSFFILNIVYWTTFL 426
            ||..||.:|...|:|||..:|
Human   421 SRILFPVAFAGFNLVYWVVYL 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	55/203 (27%)
		Neur_chan_memb	270..>350	CDD:280999	35/79 (44%)
GABRA6	NP_000802.2	Neur_chan_LBD	5..440	CDD:332142	114/408 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810