Protein Alignment HisCl1 and GABRA5

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_000801.1
• Gene: GABRA5 / 2558
• HGNCID: 4079
• Length: 462
• Species: Homo sapiens
• Alignment Length: 403
• Identity: 129/403 - (32%)
• Similarity: 195/403 - (48%)
• Gaps: 56/403 - (13%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131
            ||....|.|..:.|.|...:.|.|...:::..|.|..|:|..|||:|.|||....|..    |.:
Human    60 YDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQR----LPL 120

  Fly   132 DWL--HSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194
            :.|  ..||.||.||.|.||...|.|:.||..|.|..|.||||..:||:...|.|:.|.:|.|..
Human   121 NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAH 185

  Fly   195 ICSMMIESLSHTVEDLVFIW--NMTDPLVVNTE-IELPQLDISNNYTTDCTIEYSTGNFTCLAIV 256
            .|.:...|.::...::|::|  ..|..:||..: ..|.|..:.........|..|||.:|.:...
Human   186 ACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAH 250

  Fly   257 FNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVS 321
            |:|:|::||.:..||:|..:.|::|.:|||:..|::|||...|||::||:.|.:..::.|||.|:
Human   251 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVA 315

  Fly   322 YVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDENISDLDDLKSALQHHRESIIE 386
            |..|:|.:::.|..|||.:|:|||.||.|     ||  :|::.:....|:..|  ::..||.|:.
Human   316 YATAMDWFIAVCYAFVFSALIEFATVNYF-----TK--RGWAWDGKKALEAAK--IKKKREVILN 371

  Fly   387 PQYDTFCHG------------------HATAI--------------------YIDKFSRFFFPFS 413
            ...:.|..|                  :.|::                    .|||.||..||..
Human   372 KSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVL 436

  Fly   414 FFILNIVYWTTFL 426
            |...|:|||.|:|
Human   437 FGTFNLVYWATYL 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	65/199 (33%)
		Neur_chan_memb	270..>350	CDD:280999	35/79 (44%)
GABRA5	NP_000801.1	LGIC_ECD_GABAAR_A5	58..256	CDD:349839	65/199 (33%)
		LGIC_TM_GABAAR_alpha	259..445	CDD:349854	58/194 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..412		3/34 (9%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810