Protein Alignment HisCl1 and GABRA4

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_000800.2
• Gene: GABRA4 / 2557
• HGNCID: 4078
• Length: 554
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 121/486 - (24%)
• Similarity: 193/486 - (39%)
• Gaps: 128/486 - (26%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131
            ||....|...|..|.|...:.|.|...:::..|.|..|:|..|:|.|.||:. :...|..|:.::
Human    59 YDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKY-DGPIEILRLNNM 122

  Fly   132 DWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQIC 196
             .:..:|.||.||:|.||...|.|:.||....:..:.|:||..:||:...|.|:...:|.|...|
Human   123 -MVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHAC 186

  Fly   197 SMMIESLSHTVEDLVFIWNMTDPLVVNTEIE---LPQLDISNNYTTDCTIEYSTGNFTCLAIVFN 258
            .:...|.::...::::.|.......|....|   |.|.|:.....:..||:..||.:..:.:.|:
Human   187 PLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFH 251

  Fly   259 LRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYV 323
            |||::||.:..||||..:.|::|.:||||..|::|||...|:|::||:.|.:..::.|||.|||.
Human   252 LRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA 316

  Fly   324 KAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYS------------------------D 364
            .|:|.:::.|..|||.:|:|||.||.|......||.:..|                        :
Human   317 TAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQREKHPEAPLQNTN 381

  Fly   365 ENI-------------SDLDDLKSALQHHRESIIEPQYDT--------------FCHGHA----- 397
            .|:             ||:.:......|..:|....|..:              |...:|
Human   382 ANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQESSKGTPRSYLASSPNPFSRANAAETIS 446

  Fly   398 ----------TAI---------------------------------------------------- 400
                      |:|
Human   447 AARALPSASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPS 511

  Fly   401 -----YIDKFSRFFFPFSFFILNIVYWTTFL 426
                 .|||::|..||.:|...|:|||..:|
Human   512 GSGTSKIDKYARILFPVTFGAFNMVYWVVYL 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	55/197 (28%)
		Neur_chan_memb	270..>350	CDD:280999	37/79 (47%)
GABRA4	NP_000800.2	Neur_chan_LBD	13..541	CDD:332142	120/483 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..381		3/30 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..435		5/37 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..471		2/18 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..515		0/19 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810