DRSC/TRiP Functional Genomics Resources

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Protein Alignment HisCl1 and GABRA3

DIOPT Version :10

Sequence 1:NP_731632.1 Gene:HisCl1 / 41426 FlyBaseID:FBgn0037950 Length:426 Species:Drosophila melanogaster
Sequence 2:NP_000799.1 Gene:GABRA3 / 2556 HGNCID:4077 Length:492 Species:Homo sapiens


Alignment Length:415 Identity:126/415 - (30%)
Similarity:192/415 - (46%) Gaps:68/415 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131
            ||....|.|....|.|...:.|.|...:::..|.|..|:|..|:|.|.||:....|    :||.:
Human    78 YDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPM----KILPL 138

  Fly   132 DWL--HSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194
            :.|  ..||.||.||.|.||...|.|:.||..|.|..:.||||..:||:...|.|..|.:|.|..
Human   139 NNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVH 203

  Fly   195 ICSMMIESLSHTVEDLVFIWNMTDPLVVNTEIE-------LPQLDISNNYTTDCTIEYSTGNFTC 252
            .|.:...|.::|..::|:.|.    |..|..:|       |.|.|:..:......|..|||.:..
Human   204 ACPLKFGSYAYTTAEVVYSWT----LGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVV 264

  Fly   253 LAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSL 317
            :...|:|:|::||.:..||:|..:.|::|.:|||:..|::|||...|||::||:.|.:..::.||
Human   265 MTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSL 329

  Fly   318 PPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDENISDLDDLKS---ALQH 379
            |.|:|..|:|.:::.|..|||.:|:|||.||.|     ||....:..:.:.:..::|.   |...
Human   330 PKVAYATAMDWFIAVCYAFVFSALIEFATVNYF-----TKRSWAWEGKKVPEALEMKKKTPAAPA 389

  Fly   380 HRESII--------------EPQYDTFCHGHA------------------------TAIY----- 401
            .:.|..              :.::.|...|.|                        |..|     
Human   390 KKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTIIASPKATYVQDSPTETKTYNSVSK 454

  Fly   402 IDKFSRFFFPFSFFILNIVYWTTFL 426
            :||.||..||..|.|.|:|||.|::
Human   455 VDKISRIIFPVLFAIFNLVYWATYV 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HisCl1NP_731632.1 LGIC_ECD_HisCl 78..262 CDD:349793 60/192 (31%)
Cys-loop 182..196 CDD:349793 5/13 (38%)
LGIC_TM_anion 265..>351 CDD:349851 36/85 (42%)
TM1 helix 265..288 CDD:349851 9/22 (41%)
TM2 helix 292..316 CDD:349851 9/23 (39%)
TM3 helix 324..350 CDD:349851 12/25 (48%)
GABRA3NP_000799.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..54
LIC 69..478 CDD:455710 125/412 (30%)
LGIC_ECD_GABAAR_A3 75..274 CDD:349837 64/203 (32%)
Cys-loop 191..205 CDD:349837 5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

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