Protein Alignment HisCl1 and GABRA3

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_000799.1
• Gene: GABRA3 / 2556
• HGNCID: 4077
• Length: 492
• Species: Homo sapiens
• Alignment Length: 415
• Identity: 126/415 - (30%)
• Similarity: 192/415 - (46%)
• Gaps: 68/415 - (16%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131
            ||....|.|....|.|...:.|.|...:::..|.|..|:|..|:|.|.||:....|    :||.:
Human    78 YDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPM----KILPL 138

  Fly   132 DWL--HSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194
            :.|  ..||.||.||.|.||...|.|:.||..|.|..:.||||..:||:...|.|..|.:|.|..
Human   139 NNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVH 203

  Fly   195 ICSMMIESLSHTVEDLVFIWNMTDPLVVNTEIE-------LPQLDISNNYTTDCTIEYSTGNFTC 252
            .|.:...|.::|..::|:.|.    |..|..:|       |.|.|:..:......|..|||.:..
Human   204 ACPLKFGSYAYTTAEVVYSWT----LGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVV 264

  Fly   253 LAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSL 317
            :...|:|:|::||.:..||:|..:.|::|.:|||:..|::|||...|||::||:.|.:..::.||
Human   265 MTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSL 329

  Fly   318 PPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDENISDLDDLKS---ALQH 379
            |.|:|..|:|.:::.|..|||.:|:|||.||.|     ||....:..:.:.:..::|.   |...
Human   330 PKVAYATAMDWFIAVCYAFVFSALIEFATVNYF-----TKRSWAWEGKKVPEALEMKKKTPAAPA 389

  Fly   380 HRESII--------------EPQYDTFCHGHA------------------------TAIY----- 401
            .:.|..              :.::.|...|.|                        |..|
Human   390 KKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTIIASPKATYVQDSPTETKTYNSVSK 454

  Fly   402 IDKFSRFFFPFSFFILNIVYWTTFL 426
            :||.||..||..|.|.|:|||.|::
Human   455 VDKISRIIFPVLFAIFNLVYWATYV 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	64/203 (32%)
		Neur_chan_memb	270..>350	CDD:280999	35/79 (44%)
GABRA3	NP_000799.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..54
		LIC	69..478	CDD:273305	125/412 (30%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	64/203 (32%)
		Cys-loop	191..205	CDD:349837	5/13 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810