Protein Alignment HisCl1 and GABRA2

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001317619.1
• Gene: GABRA2 / 2555
• HGNCID: 4076
• Length: 511
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 130/462 - (28%)
• Similarity: 204/462 - (44%)
• Gaps: 115/462 - (24%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRL--PENMSEQYRIL 129
            ||....|.|....|.|:.::.|.|...:::..|.|..|:|..|.|:|.||:.  |.|:.....::
Human    53 YDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLM 117

  Fly   130 DVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194
                ...||.||.||.|.||...|.|::||..|.:..|.||||..:||:...|.|..|.:|.|..
Human   118 ----ASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAH 178

  Fly   195 ICSMMIESLSHTVEDLVFIW--NMTDPLVVNTE-IELPQLDISNNYTTDCTIEYSTGNFTCLAIV 256
            .|.:...|.::|..::.:||  |.:|.:.|..: ..|.|.|:........||:.|||.:|.:...
Human   179 SCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAH 243

  Fly   257 FNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVS 321
            |:|:|::||.:..||:|..:.|::|.:|||:..|::|||...|||::||:.|.:..::.|||.|:
Human   244 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVA 308

  Fly   322 YVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDENISDLDD-------------- 372
            |..|:|.:::.|..|||.:|:|||.||.|     ||  :|::.:..|.::|
Human   309 YATAMDWFIAVCYAFVFSALIEFATVNYF-----TK--RGWAWDGKSVVNDKSPSIKAEGITLTY 366

  Fly   373 --LKSALQHHRESIIEPQYDTF-------------------C------------------HGHAT 398
              :|:.||..:  :|..:|..|                   |                  :.:|.
Human   367 NSVKAILQGAK--LIWSKYIAFSWPSLFQEKTLEYLEKWMDCLTFKQSSKKEKASVMIQNNAYAV 429

  Fly   399 AI--------------------------------------------YIDKFSRFFFPFSFFILNI 419
            |:                                            .||:.||..||..|...|:
Human   430 AVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNL 494

  Fly   420 VYWTTFL 426
            |||.|:|
Human   495 VYWATYL 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	64/199 (32%)
		Neur_chan_memb	270..>350	CDD:280999	35/79 (44%)
GABRA2	NP_001317619.1	LIC	25..500	CDD:273305	128/459 (28%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	64/199 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910