Protein Alignment HisCl1 and GABRA1

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_000797.2
• Gene: GABRA1 / 2554
• HGNCID: 4075
• Length: 456
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 126/404 - (31%)
• Similarity: 195/404 - (48%)
• Gaps: 57/404 - (14%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131
            ||....|.|..:.|.|...:.|.|...:::..|.|..|:|..|||:|.||:....|:    :|.:
Human    53 YDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMT----VLRL 113

  Fly   132 DWL--HSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194
            :.|  ..||.||.||.|.||...|.|::||..|.:..|.||||..:||:...|.|..|.:|.|..
Human   114 NNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAH 178

  Fly   195 ICSMMIESLSHTVEDLVFIWNMTDP----LVVNTEIELPQLDISNNYTTDCTIEYSTGNFTCLAI 255
            .|.:...|.::|..::|:.|. .:|    :|......|.|.|:.........::.|||.:..:..
Human   179 ACPLKFGSYAYTRAEVVYEWT-REPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTT 242

  Fly   256 VFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPV 320
            .|:|:|::||.:..||:|..:.|::|.:|||:..|::|||...|||::||:.|.:..::.|||.|
Human   243 HFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKV 307

  Fly   321 SYVKAIDVWMSSCSVFVFLSLMEFAVV------------------------------NNFMGPVA 355
            :|..|:|.:::.|..|||.:|:|||.|                              ||...|.|
Human   308 AYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTA 372

  Fly   356 TKAMKGYS--DENISDLDDLKSALQHHRESIIEPQ------YDTFCHGHATAIYIDKFSRFFFPF 412
            |......:  |..::.:  .|||....:|  ::|:      ..||    .:...||:.||..||.
Human   373 TSYTPNLARGDPGLATI--AKSATIEPKE--VKPETKPPEPKKTF----NSVSKIDRLSRIAFPL 429

  Fly   413 SFFILNIVYWTTFL 426
            .|.|.|:|||.|:|
Human   430 LFGIFNLVYWATYL 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	62/200 (31%)
		Neur_chan_memb	270..>350	CDD:280999	35/109 (32%)
GABRA1	NP_000797.2	LIC	14..442	CDD:273305	124/401 (31%)
		LGIC_ECD_GABAAR_A1	56..249	CDD:349835	60/197 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810