Protein Alignment HisCl1 and Gabrp

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_666129.1
• Gene: Gabrp / 216643
• MGIID: 2387597
• Length: 440
• Species: Mus musculus
• Alignment Length: 434
• Identity: 128/434 - (29%)
• Similarity: 208/434 - (47%)
• Gaps: 55/434 - (12%)

  Fly    33 CVHGYRNNTESAELVSHYESSLSLPDILPIPSKTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEE 97
            |:.|.:.|.|.:.     ...||||....: :..|:|...|...|.|..:...:.:.|:.||:|.
Mouse    20 CIQGNQVNVEVSR-----SDKLSLPGFENL-TAGYNKFLRPNFGGDPVRIALTLDIASISSISES 78

  Fly    98 SMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYL 162
            :|.|...|:|.|.|.||||....|.|   ..||...:..:|.||.:...:||...||:::.|..:
Mouse    79 NMDYTATIYLRQRWTDPRLVFEGNKS---FTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLI 140

  Fly   163 WLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTE-I 226
            .|:.:.|:||..::|..::|.|....||.|||.|.:.:||..:...|:.|.|...:..|...| :
Mouse   141 RLFSNGTVLYALRITTTVTCNMDLSKYPMDTQTCKLQLESWGYDGNDVEFSWLRGNDSVRGLENL 205

  Fly   227 ELPQLDISNNYTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEA 291
            .|.|..|...:|.....:..|||:|.|.:.|.|||.:.|.:..||:||..:||:||:||||..::
Mouse   206 RLAQYTIQQYFTLVTVSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDS 270

  Fly   292 IPARVTLGVTSLLTLATQNTQSQQSLPPVS-YVKAIDVWMSSCSVFVFLSLMEFAV--------- 346
            :|||..:|||::|::.|....|:.|||..: ::|||||::..|..|||.:|:|:||
Mouse   271 VPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQM 335

  Fly   347 -----------------------VNNFMGPVATKAMK------GYSDENISDLDDLKSALQHHRE 382
                                   :::|...::..:::      .|||..:...|..|...:....
Mouse   336 AVKDRGPAKDSEEVNITNIINSSISSFKRKISFASIEISGDNVNYSDLTMKASDKFKFVFREKIS 400

  Fly   383 SIIEPQYDTFCHGHATAIYIDKFSRFFFPFSFFILNIVYWTTFL 426
            .||:  |.|.    .....:|::|:..||..|.:.|:.||..::
Mouse   401 RIID--YFTI----QNPSNVDRYSKLLFPLIFMLANVFYWAYYM 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	59/184 (32%)
		Cys-loop	182..196	CDD:349793	7/13 (54%)
		LGIC_TM_anion	265..>351	CDD:349851	38/118 (32%)
		TM1 helix	265..288	CDD:349851	12/22 (55%)
		TM2 helix	292..316	CDD:349851	9/23 (39%)
		TM3 helix	324..350	CDD:349851	13/57 (23%)
Gabrp	NP_666129.1	LIC	43..437	CDD:455710	120/403 (30%)
		LGIC_ECD	60..241	CDD:475126	59/183 (32%)