Protein Alignment HisCl1 and Gabrr3

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_620252.1
• Gene: Gabrr3 / 192258
• RGDID: 621564
• Length: 464
• Species: Rattus norvegicus
• Alignment Length: 461
• Identity: 141/461 - (30%)
• Similarity: 222/461 - (48%)
• Gaps: 60/461 - (13%)

  Fly    15 IALAIYLHALEQSIQHCHCVHGYRNNTESAELVSHYESSLSLPDILPI-PSK--------TYDKN 70
            |.|.:...|:::..|.|         ..|.:.....|:.:...|:..: |.|        .:|.:
  Rat    15 ITLMLDASAVKEPHQQC---------LSSPKQTRIRETRMRKDDLTKVWPLKREQLLHIEDHDFS 70

  Fly    71 RAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVDWLH 135
            ..|...|.|..|...|.|.|:|||:|.:|.:....:|...|:|.||..|...::. ...|...:.
  Rat    71 TRPGFGGSPVPVGIDVQVESIDSISEVNMDFTMTFYLRHYWKDERLSFPSTTNKS-MTFDRRLIQ 134

  Fly   136 SIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMI 200
            .||.||.||.::|:...|:.::.|..|.::.|..:|:..::|:...|.|.|..:|.|||.||:.:
  Rat   135 KIWVPDIFFVHSKRSFIHDTTVENIMLRVHPDGNVLFSLRITVSAMCFMDFSRFPLDTQNCSLEL 199

  Fly   201 ESLSHTVEDLVFIWNMTDPLVVNTE--IELPQLDISN-NYTTDCTIEYSTGNFTCLAIVFNLRRR 262
            ||.::..|||:..|...:. .:|||  |.|.|..|.. :.::......|||.:..|.|.|.|||.
  Rat   200 ESYAYNEEDLMLYWKHGNK-SLNTEEHISLSQFFIEEFSASSGLAFYSSTGWYYRLFINFVLRRH 263

  Fly   263 LGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAID 327
            :.:.:..||.|:.|:|::||:||||...|:||||:||:|::||::|..|....|:|.||||||:|
  Rat   264 IFFFVLQTYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIVTGVSASMPQVSYVKAVD 328

  Fly   328 VWMSSCSVFVFLSLMEFAVVN-----------NFMGPV-------ATKAM--KGYSDENISDLDD 372
            |:|...|:|||||::|:|.||           |..|.:       |.:||  .|...:..:|:|.
  Rat   329 VYMWVSSLFVFLSVIEYAAVNYLTTVEEWKQLNRRGKISGMYNIDAVQAMAFDGCYHDGETDVDQ 393

  Fly   373 LKSALQHHRESIIEPQYDTFC-----------HGHATAI------YIDKFSRFFFPFSFFILNIV 420
            ....|....:|:......:.|           .|:...|      .||.:||..||..:.|.|:.
  Rat   394 TSFFLHSEEDSMRTKFTGSPCADSSQIKRKSLGGNVGRIILENNHVIDTYSRIVFPVVYIIFNLF 458

  Fly   421 YWTTFL 426
            ||..::
  Rat   459 YWGIYV 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	60/186 (32%)
		Cys-loop	182..196	CDD:349793	7/13 (54%)
		LGIC_TM_anion	265..>351	CDD:349851	45/96 (47%)
		TM1 helix	265..288	CDD:349851	10/22 (45%)
		TM2 helix	292..316	CDD:349851	11/23 (48%)
		TM3 helix	324..350	CDD:349851	15/36 (42%)
Gabrr3	NP_620252.1	LIC	58..463	CDD:455710	131/406 (32%)
		LGIC_ECD	79..264	CDD:475126	61/186 (33%)
		Interaction with SQSTM1. /evidence=ECO:0000269|PubMed:12431995	344..445		19/100 (19%)