Protein Alignment HisCl1 and Gabrr3

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_620252.1
• Gene: Gabrr3 / 192258
• RGDID: 621564
• Length: 464
• Species: Rattus norvegicus
• Alignment Length: 461
• Identity: 141/461 - (30%)
• Similarity: 222/461 - (48%)
• Gaps: 60/461 - (13%)

  Fly    15 IALAIYLHALEQSIQHCHCVHGYRNNTESAELVSHYESSLSLPDILPI-PSK--------TYDKN 70
            |.|.:...|:::..|.|         ..|.:.....|:.:...|:..: |.|        .:|.:
  Rat    15 ITLMLDASAVKEPHQQC---------LSSPKQTRIRETRMRKDDLTKVWPLKREQLLHIEDHDFS 70

  Fly    71 RAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVDWLH 135
            ..|...|.|..|...|.|.|:|||:|.:|.:....:|...|:|.||..|...::. ...|...:.
  Rat    71 TRPGFGGSPVPVGIDVQVESIDSISEVNMDFTMTFYLRHYWKDERLSFPSTTNKS-MTFDRRLIQ 134

  Fly   136 SIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMI 200
            .||.||.||.::|:...|:.::.|..|.::.|..:|:..::|:...|.|.|..:|.|||.||:.:
  Rat   135 KIWVPDIFFVHSKRSFIHDTTVENIMLRVHPDGNVLFSLRITVSAMCFMDFSRFPLDTQNCSLEL 199

  Fly   201 ESLSHTVEDLVFIWNMTDPLVVNTE--IELPQLDISN-NYTTDCTIEYSTGNFTCLAIVFNLRRR 262
            ||.::..|||:..|...:. .:|||  |.|.|..|.. :.::......|||.:..|.|.|.|||.
  Rat   200 ESYAYNEEDLMLYWKHGNK-SLNTEEHISLSQFFIEEFSASSGLAFYSSTGWYYRLFINFVLRRH 263

  Fly   263 LGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAID 327
            :.:.:..||.|:.|:|::||:||||...|:||||:||:|::||::|..|....|:|.||||||:|
  Rat   264 IFFFVLQTYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIVTGVSASMPQVSYVKAVD 328

  Fly   328 VWMSSCSVFVFLSLMEFAVVN-----------NFMGPV-------ATKAM--KGYSDENISDLDD 372
            |:|...|:|||||::|:|.||           |..|.:       |.:||  .|...:..:|:|.
  Rat   329 VYMWVSSLFVFLSVIEYAAVNYLTTVEEWKQLNRRGKISGMYNIDAVQAMAFDGCYHDGETDVDQ 393

  Fly   373 LKSALQHHRESIIEPQYDTFC-----------HGHATAI------YIDKFSRFFFPFSFFILNIV 420
            ....|....:|:......:.|           .|:...|      .||.:||..||..:.|.|:.
  Rat   394 TSFFLHSEEDSMRTKFTGSPCADSSQIKRKSLGGNVGRIILENNHVIDTYSRIVFPVVYIIFNLF 458

  Fly   421 YWTTFL 426
            ||..::
  Rat   459 YWGIYV 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	63/197 (32%)
		Neur_chan_memb	270..>350	CDD:280999	44/90 (49%)
Gabrr3	NP_620252.1	LIC	58..463	CDD:273305	131/406 (32%)
		LGIC_ECD	79..264	CDD:355788	61/186 (33%)
		Cys-loop	181..195	CDD:349787	7/13 (54%)
		Interaction with SQSTM1. /evidence=ECO:0000269|PubMed:12431995	344..445		19/100 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810