Protein Alignment HisCl1 and lgc-57

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_496306.2
• Gene: lgc-57 / 191636
• WormBaseID: WBGene00001586
• Length: 473
• Species: Caenorhabditis elegans
• Alignment Length: 465
• Identity: 139/465 - (29%)
• Similarity: 229/465 - (49%)
• Gaps: 64/465 - (13%)

  Fly    17 LAIYLHALEQSIQHCHCVHGYRNNTESAELVSHYESSLSLPDILPIPSK--TYDKNRAPKLLGQ- 78
            |.|.:::|.|      ||.|.....:..|.|:..|....:.|:..|..:  .|::|..| ||.|
 Worm     6 LKILIYSLMQ------CVLGQAEFWDYDENVTQIEEDFKIDDVTRILKRVGNYNRNAYP-LLDQD 63

  Fly    79 -PTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVDWLHSIWRPDC 142
             .|.|...:.:..:.|.:.:||.:..||:..:.|.|.||:  .|.:::..:.|......:|.||.
 Worm    64 LATHVDIQMYIEGMSSFHAQSMDFQVDIYFQEKWVDHRLQ--HNNTKRILVKDPKLFGLLWHPDL 126

  Fly   143 FFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTV 207
            :|.||:..:||:::.||..:|:|.:.|:.|..:::|.:.|......||.|:|.|.:.|.|.::..
 Worm   127 YFANARTASFHDVTQPNFLVWIYPNGTVWYDCRISLTVLCMQDLARYPLDSQNCGLRILSYAYDE 191

  Fly   208 EDLVFIWNMTDPLVVNTEIELPQLDISNNYTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYI 272
            |.|:..||..:|:.||..|.:|.:.:.:........:|:||.::.....|::.|.:.:|:..:||
 Worm   192 EQLIIRWNGGNPVEVNRGIRMPDMHLKHIKFYTKRDKYATGIWSSAVAEFHVDREITHHIIQSYI 256

  Fly   273 PSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFV 337
            |::|||::||.|||:..||:|.||:|.:|:|||||||::.::.:||..|.||||||||.:|..||
 Worm   257 PTSLIVIISWFSFWLDVEAVPGRVSLSITTLLTLATQSSAARMALPQASDVKAIDVWMGTCMAFV 321

  Fly   338 FLSLMEFAVVNNFM-GPVATKAM-KGYSDE----------------------------------- 365
            |.:::||.|||..: ..|.||.. :|.|::
 Worm   322 FSAMIEFTVVNYCVRRKVRTKIKPRGLSEQVHDMVAQYREKKDKFNNGNCEISYEMALQPNEDNA 386

  Fly   366 --------------NISDLDDLKSALQHHRESIIEPQYDTFCHGHATAIYIDKFSRFFFPFSFFI 416
                          |.:.|...:|.|...:...||.:.:........|..||::||..||.:|.|
 Worm   387 TVQRNFEKKEVREMNQASLFVRRSLLPTSKRKTIEDRINRVEENRKNAQKIDRYSRALFPLAFII 451

  Fly   417 LNIVYWTTFL 426
            .||.||..:|
 Worm   452 FNIFYWIYYL 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	50/185 (27%)
		Cys-loop	182..196	CDD:349793	5/13 (38%)
		LGIC_TM_anion	265..>351	CDD:349851	46/85 (54%)
		TM1 helix	265..288	CDD:349851	12/22 (55%)
		TM2 helix	292..316	CDD:349851	12/23 (52%)
		TM3 helix	324..350	CDD:349851	16/25 (64%)
lgc-57	NP_496306.2	LIC	44..460	CDD:455710	127/418 (30%)