Protein Alignment HisCl1 and lgc-42

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001391137.1
• Gene: lgc-42 / 189722
• WormBaseID: WBGene00021437
• Length: 413
• Species: Caenorhabditis elegans
• Alignment Length: 402
• Identity: 134/402 - (33%)
• Similarity: 205/402 - (50%)
• Gaps: 58/402 - (14%)

  Fly    62 IPSKTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQY 126
            :..|...:|..||   .|..|:|...|.||.:.....|||..|::|..||:|..:|  .|.:|..
 Worm    26 LQDKPMPRNGNPK---APLQVHFGFYVESLGNFRATEMTYDMDMYLYMSWQDDSMR--HNETEHV 85

  Fly   127 RILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPH 191
            .:.|.|.|..||.||.:|.||:...||::::.|..:::....|:.|.:::||.|:|.:..:.||.
 Worm    86 LVNDKDILDKIWLPDLYFANARTAYFHKVTVHNFNMFISPQGTISYGTRVTLNLACNLDLKDYPL 150

  Fly   192 DTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTEIELPQLDI---SNNYTTDC---TIEYST--- 247
            |.|.|.:.:.|.:|...::...|...||:..|.||:||:..|   ..:|....   |:.:::
 Worm   151 DYQTCYIKVISYAHVKNEMNVSWFPNDPIRFNPEIDLPEFHIRALDKDYCNGVFLYTLTHNSSRV 215

  Fly   248 GNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQ 312
            |.|:||..:..|:|.:|:||..:|||:.|||.:||:||||...|:||||:|..|:||||:||...
 Worm   216 GEFSCLLGMLKLKRAIGFHLVQSYIPTGLIVAISWVSFWIDRRAVPARVSLSFTTLLTLSTQGNG 280

  Fly   313 SQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFM------GPVATKAMKGYSDENI---- 367
            .:.:||.|||.||||.:...|.:|:|..|:|||.||::|      ..:|.|....|..:.|
 Worm   281 IRYALPAVSYAKAIDYFYGVCMLFIFGVLLEFAAVNSYMRRANKYNHMAEKIQSAYGGKPIIAAD 345

  Fly   368 --SDLDD----------------LKSALQHHRESIIEPQYDTFCHGHATAIYIDKFSRFFFPFSF 414
              ||.::                :..||:..|:                |:.|||.:||.||..|
 Worm   346 YDSDYEEGPTKYYGNLNKNSAHLMYKALKFSRK----------------ALSIDKAARFAFPCVF 394

  Fly   415 FILNIVYWTTFL 426
            .|.|:.||..:|
 Worm   395 AIFNVFYWLYYL 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	59/192 (31%)
		Cys-loop	182..196	CDD:349793	5/13 (38%)
		LGIC_TM_anion	265..>351	CDD:349851	45/85 (53%)
		TM1 helix	265..288	CDD:349851	13/22 (59%)
		TM2 helix	292..316	CDD:349851	12/23 (52%)
		TM3 helix	324..350	CDD:349851	13/25 (52%)
lgc-42	NP_001391137.1	LIC	32..405	CDD:455710	132/393 (34%)