Protein Alignment HisCl1 and lgc-45

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001335538.1
• Gene: lgc-45 / 189345
• WormBaseID: WBGene00021146
• Length: 1046
• Species: Caenorhabditis elegans
• Alignment Length: 397
• Identity: 135/397 - (34%)
• Similarity: 218/397 - (54%)
• Gaps: 25/397 - (6%)

  Fly    38 RNNTESAELVSHYESS---LSLPDILPIPSKT-YDKNRAPKLL-GQPTVVYFHVTVLSLDSINEE 97
            ||:||..|::|....|   |....|||:.:|. ||...||.:. |...||.|.:.:.|:.:....
 Worm   654 RNDTEVDEILSRTNGSTKNLGGSFILPVLNKNQYDPFSAPIVFQGSAVVVRFGIYIESMSNFQTS 718

  Fly    98 SMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYL 162
            :|.|..||:|..||||.||..|  ..:...:.:.|.|..|||||.||.|||:..|||::..|..:
 Worm   719 TMDYDMDIYLMMSWRDARLVNP--YDKPILVKEEDILEKIWRPDPFFANAKEAEFHEVTFLNFLM 781

  Fly   163 WLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIW--NMTDPLVVNTE 225
            .::.|..:||.:::.:..||.:....||||.|.|.::|:|.::.||.:.|.|  ...|.:..|.:
 Worm   782 RIFPDGLVLYETRVKIKPSCNLILCKYPHDKQTCDLLIKSFAYPVETVRFEWFTRRKDAIDKNPD 846

  Fly   226 IELPQLDISNNYTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPE 290
            ::||:|.|....||.|..|..:|.|:||..||.|:|.:|:|:..||||::|.::.||:..|:..|
 Worm   847 VKLPELYIDRYETTTCPNERKSGAFSCLRAVFRLKRDVGFHIAQTYIPTSLALMFSWVGVWLPEE 911

  Fly   291 AIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVA 355
            .:..|:.:.:|.||||:|::..:::.||.|||:||||:|....:.|||.:|::...|..|  ...
 Worm   912 FMEGRIGVAITVLLTLSTESAGAREHLPSVSYLKAIDLWFGFITGFVFFTLLQTLFVIGF--DKR 974

  Fly   356 TKAMKGYSDENISDLDDLKSALQHHRESIIE--PQYDTFCHGHATAIYIDKFSRFFFPFSFFILN 418
            ...:|.::....:|:      .:..||::::  .:|      |.|..|:|.|.|.|:|.||.:..
 Worm   975 ANQLKKWAGRKTADI------TEEIREALLQKATRY------HKTGRYLDNFCRVFYPLSFILFL 1027

  Fly   419 IVYWTTF 425
            ::|:..|
 Worm  1028 LMYYFVF 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	66/185 (36%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	32/85 (38%)
		TM1 helix	265..288	CDD:349851	9/22 (41%)
		TM2 helix	292..316	CDD:349851	7/23 (30%)
		TM3 helix	324..350	CDD:349851	10/25 (40%)
lgc-45	NP_001335538.1	LIC	687..>969	CDD:455710	104/283 (37%)