Protein Alignment HisCl1 and lgc-40

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001407536.1
• Gene: lgc-40 / 188854
• WormBaseID: WBGene00020767
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 513
• Identity: 127/513 - (24%)
• Similarity: 228/513 - (44%)
• Gaps: 123/513 - (23%)

  Fly    21 LHALEQSIQHCHCVHGYRNNTESAELVSHYESSLSLPDILPIPSKTYDKNRAPKL---------- 75
            ||.:.:.:....|:   .|..|||:|.           .:|:.....||.:...|
 Worm     3 LHTMIRFLLSVCCI---VNVFESADLA-----------FIPLTKAFLDKLKNETLYNRFATPTQY 53

  Fly    76 --------LGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVD 132
                    .|.||.|...:.:..:.|.:.::|.|..|::..:.|.|.  ||..|.|....:.|:.
 Worm    54 DEYIRVHGTGVPTNVTLSMFIEGMSSFSAQTMDYHLDVYFQEEWYDH--RLAHNASAPILVRDLT 116

  Fly   133 WLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICS 197
            ....:|.||.:|.||:...|.:::..|..:|:|.:..:.|.:::::|.||.|....||.|:|.|:
 Worm   117 VFKMMWHPDVYFANARSAAFQDITDDNFLVWVYPNGRVWYDARISIVSSCNMDLWKYPLDSQECA 181

  Fly   198 MMIESLSHTVEDLVFIWNMTDPLVV---NTEIELPQLDISNNYTTDCTIEYSTGNFTCLAIVFNL 259
            :.|.|.::.:..|..:|:..:.:..   |.:|.:|.:.:.:..|..|...|:||.::|:..:|.:
 Worm   182 LRILSYAYPMTVLRLLWSEKEDVPAIDRNPDITMPDMSLKHIRTGYCNGTYATGEWSCMTAIFYV 246

  Fly   260 RRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVK 324
            .|.:.:|:..||:|:|||||:||.:||::.::.||||:|.:|:|||::||....:.:||.|||:|
 Worm   247 EREMMHHVMQTYVPTALIVVISWFNFWLEIDSAPARVSLSITTLLTISTQANAVKLALPEVSYMK 311

  Fly   325 AIDVWMSSCSVFVFLSLMEFAV---------------------------------VNNFMGPVAT 356
            ||||||.||..|||..::||.:                                 :::.:..|||
 Worm   312 AIDVWMGSCMAFVFGVMIEFTICHYAKNLEMLRGDGQPSLIVDTALSTLFGAARDIDDLVRKVAT 376

  Fly   357 ----KAMKGYSDENI---------------SDLDDL-------------------KSALQHHRES 383
                :.::|..:::|               :..:|:                   |::|...|:.
 Worm   377 LNEEEGVRGDGEQHIALNMLNPEEPRLRSLNQNNDVTANGTRYFVGAERMKRKRSKASLSRLRQQ 441

  Fly   384 IIEPQYDTF---------------CHGHATAIYIDKFSRFFFPFSFFILNIVYWTTFL 426
            :...::.|.               ..|...|..||:..|..||..|.:.|:.||:.:|
 Worm   442 VASMRHATIDVSRRAFNWTRALRNLRGRRVAQRIDERCRIVFPMIFLLFNVAYWSFYL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	48/186 (26%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	43/118 (36%)
		TM1 helix	265..288	CDD:349851	13/22 (59%)
		TM2 helix	292..316	CDD:349851	11/23 (48%)
		TM3 helix	324..350	CDD:349851	14/58 (24%)
lgc-40	NP_001407536.1	LIC	31..498	CDD:455710	117/468 (25%)