Protein Alignment HisCl1 and lgc-53

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_741945.3
• Gene: lgc-53 / 188702
• WormBaseID: WBGene00020657
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 476
• Identity: 130/476 - (27%)
• Similarity: 211/476 - (44%)
• Gaps: 103/476 - (21%)

  Fly    44 AELVSHYESSLSLPDILP--------IPSK----------------------------------- 65
            ||:.::.|.|:.|..:.|        |||.
 Worm    25 AEIAANQEHSIQLDQMPPDRTFHYPNIPSSQHDRRREGGKRKKFRKERLDEPCTAINETLRKNLL 89

  Fly    66 ------TYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSE 124
                  :||||..|.  ...|.|...:||.|:..|:|.|.::..|::.:|.||||||...:   .
 Worm    90 QELFDDSYDKNNLPS--ANSTEVIVELTVQSITEISEFSSSFKADVWFSQIWRDPRLDFSD---R 149

  Fly   125 QYRILDVDW----LHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMK 185
            .|.:.::..    |.::|.|:..|.|:|||..|.....|..|.::.:.|:....:::|...|.:.
 Worm   150 NYCLKNISLASHKLPTMWSPNVCFVNSKKVEIHASPSQNILLLIFPNGTVWLNFRVSLTGPCKLD 214

  Fly   186 FESYPHDTQICSMMIESLSHTVEDLVFIWNMTDPLVV--NTEIELPQLDISNNYTTDCTIEYSTG 248
            ...:|.|.|.|:::.||.|:...::..:|...|.:.:  .....||..::.|....:.|:.|:.|
 Worm   215 LTYFPMDRQSCNLVFESYSYNTAEVRIVWRDWDAVTIPDPDSKNLPDFELVNIEHMNATLVYTAG 279

  Fly   249 NFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQS 313
            .:..|.:.|..||..||::...|:|:.|.|.:|||:|||..:|:|||:||||:||:.|..|....
 Worm   280 LWDQLEVKFTFRRLYGYYVLQAYMPTYLSVFISWIAFWIDTKALPARITLGVSSLMALTFQFGNI 344

  Fly   314 QQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATK-----------AMKGYSDE-- 365
            .::||.||||||:|:||..|..|:||||:|.||| .|...:..|           .|:..|::
 Worm   345 VKNLPRVSYVKALDIWMFGCVGFIFLSLVELAVV-GFADKLEAKRRRHNRCKEQLMMRSDSEQQW 408

  Fly   366 ---------NISDLD-DLKSALQ--------HHRES-------IIEPQYDTFCHGHATAIYIDKF 405
                     .:|:.: |....:|        ..|:|       :::.:...|.:|..    ||:.
 Worm   409 LSRLSGQRPQVSETNSDATHTIQINDGNGNVRRRKSEEKRQKLLLQMESPMFVNGEK----IDEI 469

  Fly   406 SRFFFPFSFFILNIVYWTTFL 426
            |...||..|...||.||..::
 Worm   470 SAKLFPLLFTAFNIFYWFYYI 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	49/189 (26%)
		Cys-loop	182..196	CDD:349793	4/13 (31%)
		LGIC_TM_anion	265..>351	CDD:349851	44/85 (52%)
		TM1 helix	265..288	CDD:349851	10/22 (45%)
		TM2 helix	292..316	CDD:349851	11/23 (48%)
		TM3 helix	324..350	CDD:349851	15/25 (60%)
lgc-53	NP_741945.3	LIC	87..489	CDD:455710	121/411 (29%)
		LGIC_ECD_GABAAR	108..292	CDD:349791	48/186 (26%)
		Cys-loop	211..225	CDD:349791	4/13 (31%)