Protein Alignment HisCl1 and lgc-54

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001343648.1
• Gene: lgc-54 / 188525
• WormBaseID: WBGene00020528
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 419
• Identity: 116/419 - (27%)
• Similarity: 188/419 - (44%)
• Gaps: 66/419 - (15%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLP------ENMSEQ 125
            |:||..| |....|||.....:.::..::|.|.::..|:..:|.|.|||||..      :|::..
 Worm    64 YNKNTVP-LKTSATVVSVEFGIQNIAQVSEISASFTLDLLFSQIWHDPRLRFDHLTNCLQNLTLG 127

  Fly   126 YRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYP 190
            |.:::     .:|.|:..|.|:||...|....||.:|.:|.:.|:....:|.:...|.:....:|
 Worm   128 YSMVE-----KLWTPNVCFVNSKKTEIHSSPTPNIFLMIYPNGTVWVNYRLQVQSPCMVDLVLFP 187

  Fly   191 HDTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTEIELPQLDISNNYTTDCTIEYSTGNFTCLAI 255
            .|...|.::|||.::....:...|....|:....:.:|....:.....|..:.||:.|.:..|.:
 Worm   188 MDIMNCELIIESYAYNAAKVKLNWREWQPVFSIAKSKLSDFTLYGLQWTKNSFEYAAGQWDQLTV 252

  Fly   256 VFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPV 320
            .....|..|:::...|||:...|.:|::||||..:|:|||:||||:||:.|..|.....::||.|
 Worm   253 SLTFSRAYGFYILQMYIPTYSSVFLSFVSFWIDLKALPARITLGVSSLMALTFQYGNVAKNLPRV 317

  Fly   321 SYVKAIDVWMSSCSVFVFLSLMEFAVV----------------------------------NNFM 351
            .|||:|||:|...:.|:||:::|.|.|                                  ||:.
 Worm   318 GYVKSIDVYMVLTTAFIFLTMIEVAFVCYLDSENNLRRKERQAEKKKERVAVLQRKKDRKKNNYG 382

  Fly   352 GPVATKAMKGYSDENISDLDD--LKSALQHHRESIIEPQYDTFCHGHA----------------- 397
            ....|.|....||.. |:.|:  .::....|:.||.....:.|...||
 Worm   383 ATTVTNANAAESDLR-SNYDEPFSQNGTTSHKISISRQANNMFESLHALAQFGLLTDDDDENTKW 446

  Fly   398 TAIYIDKFSRFFFPFSFFILNIVYWTTFL 426
            ||..:|||.|..||.||..||::||..:|
 Worm   447 TAQNVDKFCRKAFPLSFCFLNLIYWCYYL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	43/189 (23%)
		Cys-loop	182..196	CDD:349793	3/13 (23%)
		LGIC_TM_anion	265..>351	CDD:349851	39/119 (33%)
		TM1 helix	265..288	CDD:349851	8/22 (36%)
		TM2 helix	292..316	CDD:349851	11/23 (48%)
		TM3 helix	324..350	CDD:349851	12/59 (20%)
lgc-54	NP_001343648.1	LIC	55..474	CDD:455710	115/416 (28%)
		LGIC_ECD_GABAAR	76..258	CDD:349791	43/186 (23%)
		Cys-loop	179..193	CDD:349791	3/13 (23%)