Protein Alignment HisCl1 and lgc-48

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_506308.3
• Gene: lgc-48 / 183638
• WormBaseID: WBGene00008223
• Length: 366
• Species: Caenorhabditis elegans
• Alignment Length: 366
• Identity: 106/366 - (28%)
• Similarity: 172/366 - (46%)
• Gaps: 52/366 - (14%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPE------NMSEQ 125
            |.|::.|:..|....|.|.:.  .::||:|.:..:..::|:.:.|.||.||.|.      |::
 Worm    41 YSKHKIPRENGITVSVEFWIQ--EINSISEMTNDFELELFINEMWTDPSLRFPHLGACKANLT-- 101

  Fly   126 YRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYP 190
               ||...|..:|.|:..|.|:|....:|.|..|.:|.|:.:.|:....::.:..:|.|....:|
 Worm   102 ---LDQQTLTKLWTPNTCFVNSKFAEIYESSFQNVFLTLFDNGTVWVNYRVRVKGACNMDLVDFP 163

  Fly   191 HDTQICSMMIESLSHTVEDLVFIWN-MTDPLVVNTEIELPQLDISNNYTTDCTIEYSTGNFTCLA 254
            .|||.|.:..:|.::..|::...|| ...|:....||.:....:.:........:|..|.:..|.
 Worm   164 MDTQSCRLNYQSFTYNNEEVRLQWNSQRSPVFALQEIRIADFWLKDITPAVIKRDYPAGLWDELV 228

  Fly   255 IVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPP 319
            :.|...||..::....|:|:...:.:|||:|.:.|:||..|..:||.:||::........::||.
 Worm   229 VTFVFERRYMWYFLQAYLPTFFSIFISWIAFSLGPQAITPRTMIGVNALLSMIFHFGSIMKNLPR 293

  Fly   320 VSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDENISDLDDLKSALQHHRESI 384
            |||:|||||||.|...||||||:|.|:|             ||           |..:|..:|.:
 Worm   294 VSYIKAIDVWMLSSMTFVFLSLIELAIV-------------GY-----------KLQIQREKEHV 334

  Fly   385 IEPQYDTFCHGHATAIYIDKFSRFFFPFSFFILNIVYWTTF 425
            ||.              :||.:||.||..|.|.||:||..:
 Worm   335 IEK--------------VDKIARFAFPAGFSIFNIIYWARY 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	45/190 (24%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	36/85 (42%)
		TM1 helix	265..288	CDD:349851	6/22 (27%)
		TM2 helix	292..316	CDD:349851	6/23 (26%)
		TM3 helix	324..350	CDD:349851	17/25 (68%)
lgc-48	NP_506308.3	LGIC_ECD_GABAAR	52..236	CDD:349791	45/190 (24%)
		Cys-loop	155..169	CDD:349791	6/13 (46%)
		LGIC_TM_anion	239..358	CDD:349851	53/156 (34%)
		TM1 helix	239..262	CDD:349851	6/22 (27%)
		TM2 helix	266..290	CDD:349851	6/23 (26%)
		TM3 helix	298..324	CDD:349851	19/49 (39%)
		TM4 helix	325..358	CDD:349851	14/46 (30%)