Protein Alignment HisCl1 and glc-1

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_507090.1
• Gene: glc-1 / 180086
• WormBaseID: WBGene00001591
• Length: 461
• Species: Caenorhabditis elegans
• Alignment Length: 424
• Identity: 142/424 - (33%)
• Similarity: 224/424 - (52%)
• Gaps: 43/424 - (10%)

  Fly    39 NNTESAELVSHYESSLSLPDILPIPSKT----------YD-KNRAPKLLGQPTVVYFHVTVLSLD 92
            |.|.:.|.::...|.:.:|...|..|.:          || :.|.|...|.|.||..::.:.::.
 Worm    37 NGTTTLESLARLTSPIHIPIEQPQTSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTIS 101

  Fly    93 SINEESMTYVTDIFLAQSWRDPRLR--LPENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEM 155
            .|:..:|.|...:.|.:||.|.||.  :..:....:.||.|.  |.||.||.||.|.|:...|.:
 Worm   102 KIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVG--HQIWMPDTFFPNEKQAYKHTI 164

  Fly   156 SIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNMTDP- 219
            ..||..:.:::|.|:||..:::|||||.|..:.||.|.|.||:.:.|.::|.:|:.::|....|
 Worm   165 DKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPL 229

  Fly   220 -LVVNTEIELPQLDISNNYTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWI 283
             |.|.....||...::|..||.||...:||.::||.....|:|...::|...||||.::|::||:
 Worm   230 QLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWV 294

  Fly   284 SFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVN 348
            |||....|||||||||||:|||:..|:......||||||:||||||:.:|..|:|.:|:|||:||
 Worm   295 SFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVN 359

  Fly   349 NFMGPVATK---AMKGYSDENISDL-------DDLKSALQHHRESI-----IEPQYDTFCHGHAT 398
            :    :|.|   ..|..::...:::       :|:.:.:.:..|.:     ...|.::|.:...|
 Worm   360 H----IANKQGVERKARTEREKAEIPLLQNLHNDVPTKVFNQEEKVRTVPLNRRQMNSFLNLLET 420

  Fly   399 -------AIYIDKFSRFFFPFSFFILNIVYWTTF 425
                   :..:|..||..||..||:.||:||:.|
 Worm   421 KTEWNDISKRVDLISRALFPVLFFVFNILYWSRF 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	62/187 (33%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	47/85 (55%)
		TM1 helix	265..288	CDD:349851	11/22 (50%)
		TM2 helix	292..316	CDD:349851	14/23 (61%)
		TM3 helix	324..350	CDD:349851	15/25 (60%)
glc-1	NP_507090.1	LIC	65..452	CDD:455710	133/392 (34%)