Protein Alignment HisCl1 and lgc-49

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_505841.2
• Gene: lgc-49 / 179547
• WormBaseID: WBGene00010741
• Length: 457
• Species: Caenorhabditis elegans
• Alignment Length: 395
• Identity: 116/395 - (29%)
• Similarity: 186/395 - (47%)
• Gaps: 58/395 - (14%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRL------PENMSEQ 125
            |:|.|.|...|.|..|.|.|..::  ||||.:..:..||::.:.|.||.|:.      .:|:|..
 Worm    67 YNKFRIPNENGVPVQVEFWVQAIT--SINEITNDFEMDIYINEMWLDPALKFDHLNPCKQNLSVS 129

  Fly   126 YRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYP 190
            :::|:     .:|.|:..|.|:|....|:....|.:|.:|.:.|:....::.:...|.:..|.:|
 Worm   130 HQVLE-----QLWTPNSCFVNSKFAEIHDSPFKNVFLMIYPNGTVWVNYRVNVKGPCDLSLELFP 189

  Fly   191 HDTQICSMMIESLSHTVEDLVFIWN--MTDPLVVNTEIELPQLDISNNYTTDCTIEYSTGNFTCL 253
            .|.|.|.::.||.::..:::...||  ..:|:.|..:|.||..::....:|..:..|..|.:..|
 Worm   190 LDIQECHLIYESFNYNNQEVRMRWNEKSAEPVSVTNKIRLPDFELIKIESTRISAPYPAGMWDEL 254

  Fly   254 AIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLP 318
            .:.....||..::....|:|:.|.:.:|||||.:..:|:|||..|||.:||.:..|.....::||
 Worm   255 HVKLVFERRYIWYFMQAYLPTYLTIFISWISFSLGTKAMPARTMLGVNALLAMIFQFGNIMRNLP 319

  Fly   319 PVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDENISD----------LDDL 373
            .|||||||||||.....|:||||:|.|:|             ||..:|...          ||:.
 Worm   320 RVSYVKAIDVWMLVSMTFIFLSLLELAIV-------------GYKTKNEEGSKKKCPHKKLLDNF 371

  Fly   374 KSA------------LQHHRES-----IIEPQ-YDTFCHGHATAIYIDKFSRFFFPFSFFILNIV 420
            :::            |...|.|     ||..| :..|.:.....  ||:.|...||..|.|.|||
 Worm   372 EASPAGLCRYEKRFMLPVERRSARWGGIIRFQVFQDFWNWSPEK--IDRVSAIMFPACFAIFNIV 434

  Fly   421 YWTTF 425
            ||:.:
 Worm   435 YWSYY 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	46/191 (24%)
		Cys-loop	182..196	CDD:349793	5/13 (38%)
		LGIC_TM_anion	265..>351	CDD:349851	39/85 (46%)
		TM1 helix	265..288	CDD:349851	8/22 (36%)
		TM2 helix	292..316	CDD:349851	9/23 (39%)
		TM3 helix	324..350	CDD:349851	15/25 (60%)
lgc-49	NP_505841.2	LIC	53..439	CDD:455710	116/393 (30%)
		LGIC_ECD_GABAAR	78..263	CDD:349791	46/191 (24%)
		Cys-loop	181..195	CDD:349791	5/13 (38%)