Protein Alignment HisCl1 and acc-4

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001379219.1
• Gene: acc-4 / 176778
• WormBaseID: WBGene00012099
• Length: 408
• Species: Caenorhabditis elegans
• Alignment Length: 437
• Identity: 127/437 - (29%)
• Similarity: 186/437 - (42%)
• Gaps: 86/437 - (19%)

  Fly    21 LHALEQSIQHC--HCVHGYRN----NTES---------AELVSHYESSLSLPDILPIPSKTYDKN 70
            |.:||.....|  :|....||    :||.         |:::..| :.|.||.
 Worm    19 LRSLEDDSNECMFNCPKRARNVSVPHTEKTCMGDDAIIAQILDGY-NKLDLPG------------ 70

  Fly    71 RAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLR------LPENMSEQYRIL 129
                  |...||...:.|..:..|.|.:..:..||::.:.|.||.|.      ...|||
 Worm    71 ------GGHVVVSIEIWVQEVSKIIEITSEFELDIYVTERWTDPSLAYSHLNPCKSNMS------ 123

  Fly   130 DVDW---LHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPH 191
             ||.   |:.||.|...|.|:|....||....|.:|.:|.:.::.:..::.|...|:....::|.
 Worm   124 -VDGATILNKIWNPHACFVNSKLANIHESPFKNIFLQIYSNGSIWHNYRIKLTGPCSSTLRTFPI 187

  Fly   192 DTQICSMMIESLSHTVEDLVFIWNMTDP--LVVNTEIELPQ---LDISNNYTTDCTIEYSTGNFT 251
            |.|.|.:..||.:|..:.:...|..|.|  .::...|.||.   :|.|:  :::..: |..|.|.
 Worm   188 DQQRCMLFYESFTHNTDQVKMEWITTVPPITILKGNITLPDYVLVDFSS--SSELRL-YPPGIFN 249

  Fly   252 CLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQS 316
            .|...|..:|..|:::...|:|:.:.|.:||:||.:..|.||:|.|:||.|||.|..|......:
 Worm   250 ELIATFTFQRLYGFYILQVYVPAYISVFISWVSFTLGAEQIPSRTTVGVNSLLALTFQFGAVVNN 314

  Fly   317 LPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDENISDLDDLKSALQHHR 381
            ||..|.|||||||:.|...|:|.||:|.|||             ||          |....||
 Worm   315 LPKTSDVKAIDVWILSSMAFIFASLIELAVV-------------GY----------LSRDGQH-- 354

  Fly   382 ESIIEPQYDTFCHG--HATAIYIDKFSRFFFPFSFFILNIVYWTTFL 426
             ..|:.:....|..  ..||:.||:.|...||.||...||.||..||
 Worm   355 -GSIKCRCSWLCMNCKDWTALKIDQMSSIVFPVSFLAFNIWYWFIFL 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	51/208 (25%)
		Neur_chan_memb	270..>350	CDD:280999	38/79 (48%)
acc-4	NP_001379219.1	LGIC_ECD_GABAAR	74..259	CDD:349791	50/194 (26%)
		LGIC_TM_anion	263..396	CDD:349851	56/158 (35%)
		TM1 helix	266..286	CDD:349851	7/19 (37%)
		TM2 helix	295..316	CDD:349851	8/20 (40%)
		TM3 helix	326..348	CDD:349851	13/44 (30%)
		TM4 helix	375..396	CDD:349851	9/20 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810