Protein Alignment HisCl1 and glc-2

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_491470.1
• Gene: glc-2 / 172103
• WormBaseID: WBGene00001592
• Length: 434
• Species: Caenorhabditis elegans
• Alignment Length: 419
• Identity: 130/419 - (31%)
• Similarity: 203/419 - (48%)
• Gaps: 53/419 - (12%)

  Fly    46 LVSHYESSL-SLPDILPIPSKTYDKNRAPKLLGQPTV----VYFHVTVLSLDSINEESMTYVTDI 105
            :|::.|.|: |..:||....|.||....|......|.    |..::.:..|..|:..:|.|...:
 Worm    18 VVTNGEYSMQSEQEILNALLKNYDMRVRPPPANSSTEGAVNVRVNIMIRMLSKIDVVNMEYSIQL 82

  Fly   106 FLAQSWRDPRLRLPENMS--EQYRILDVDWL-HSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHD 167
            ...:.|.||||.. ||:.  .....|.|..: .|:|.||.||...|....|.:.:.|.:|.:|.|
 Worm    83 TFREQWIDPRLAY-ENLGFYNPPAFLTVPHVKKSLWIPDTFFPTEKAAHRHLIDMENMFLRIYPD 146

  Fly   168 KTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTEI--ELPQ 230
            ..:||.|:::|..||.|:.:.||.|.|.|:..:.|.:||:.|:::.|:.:.|:.:...:  :||.
 Worm   147 GKILYSSRISLTSSCPMRLQLYPLDYQSCNFDLVSYAHTMNDIMYEWDPSTPVQLKPGVGSDLPN 211

  Fly   231 LDISNNYTT--DCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIP 293
            . |..||||  |||...:||::.||.:....:|:..|:|...|.|:.:||::||:||||...:..
 Worm   212 F-ILKNYTTNADCTSHTNTGSYGCLRMQLLFKRQFSYYLVQLYAPTTMIVIVSWVSFWIDLHSTA 275

  Fly   294 ARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKA 358
            .||.||||:|||:.|..:.....||||||||.:|||:.:|..|||.:|:|:|.|:
 Worm   276 GRVALGVTTLLTMTTMQSAINAKLPPVSYVKVVDVWLGACQTFVFGALLEYAFVS---------- 330

  Fly   359 MKGYSD---ENISDLDDLKSALQHHRESIIEPQYDTF-----CHG-HATAIYIDK---------- 404
               |.|   :|....:......|..||.:.....:.:     ||. .|...:.||
 Worm   331 ---YQDSVRQNDRSREKAARKAQRRREKLEMVDAEVYQPPCTCHTFEARETFRDKVRRYFTKPDY 392

  Fly   405 -------FSRFFFPFSFFILNIVYWTTFL 426
                   ::||..|.:|...|::||.:.|
 Worm   393 LPAKIDFYARFVVPLAFLAFNVIYWVSCL 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	59/194 (30%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	41/85 (48%)
		TM1 helix	265..288	CDD:349851	11/22 (50%)
		TM2 helix	292..316	CDD:349851	10/23 (43%)
		TM3 helix	324..350	CDD:349851	12/25 (48%)
glc-2	NP_491470.1	LIC	29..419	CDD:455710	125/404 (31%)