Protein Alignment HisCl1 and Glra4

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_034427.2
• Gene: Glra4 / 14657
• MGIID: 95750
• Length: 456
• Species: Mus musculus
• Alignment Length: 397
• Identity: 150/397 - (37%)
• Similarity: 218/397 - (54%)
• Gaps: 47/397 - (11%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131
            ||....|...|.|..|..::.:.|..|:.|.:|.|..::||.|.|.||||...|...:.   ||:
Mouse    57 YDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNVFLRQQWNDPRLAYREYPDDS---LDL 118

  Fly   132 D--WLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194
            |  .|.|||:||.||.|.|...|||::..|..|.::.:..:||..:|||:|||.|..:::|.|.|
Mouse   119 DPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCPMDLKNFPMDIQ 183

  Fly   195 ICSMMIESLSHTVEDLVFIWNMTDPLVVNTE-IELPQLDISNNYTTD-CTIEYSTGNFTCLAIVF 257
            .|:|.:||..:|:.||:|.|....|.|...| :.|||..:.:..... ||..|:||.|||:.:.|
Mouse   184 TCTMQLESFGYTMNDLMFEWLEDAPAVQVAEGLTLPQFILRDEKDLGYCTKHYNTGKFTCIEVKF 248

  Fly   258 NLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSY 322
            :|.|::||:|...||||.|||::||:||||..:|.||||.||:|::||:.||::.|:.|||.|||
Mouse   249 HLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSY 313

  Fly   323 VKAIDVWMSSCSVFVFLSLMEFAVVN-------NFMGPVATKAMKGYSDENISDLDDLKSALQHH 380
            |||||:||:.|.:|||.:|:|:|.||       .|| .:..:..:...:|:|     ::.:..:.
Mouse   314 VKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFM-RLRRRQRRQRMEEDI-----IRESRFYF 372

  Fly   381 R------------------ESIIEPQYDT--FCHGHA-TAIYIDK------FSRFFFPFSFFILN 418
            |                  .||..||..|  ...|.. ..:|:|:      .||..|||:|.:.|
Mouse   373 RGYGLGHCLQARDGGPMEGSSIYSPQPPTPLLKEGETMRKLYVDRAKRIDTISRAVFPFTFLVFN 437

  Fly   419 IVYWTTF 425
            |.||..:
Mouse   438 IFYWVVY 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	75/198 (38%)
		Neur_chan_memb	270..>350	CDD:280999	48/86 (56%)
Glra4	NP_034427.2	LIC	9..444	CDD:273305	150/395 (38%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4045
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.880