Protein Alignment HisCl1 and Glra1

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001277750.1
• Gene: Glra1 / 14654
• MGIID: 95747
• Length: 457
• Species: Mus musculus
• Alignment Length: 441
• Identity: 158/441 - (35%)
• Similarity: 224/441 - (50%)
• Gaps: 73/441 - (16%)

  Fly    41 TESAELVSHYESSLSLPDIL-PIPSKT--YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYV 102
            ::.||........:|..|.| .:..:|  ||....|...|.|..|..::.:.|..||.|.:|.|.
Mouse    23 SKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYR 87

  Fly   103 TDIFLAQSWRDPRLRLPENMSEQYRILDVD--WLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLY 165
            .:|||.|.|.||||...|...:.   ||:|  .|.|||:||.||.|.|...|||::..|..|.:.
Mouse    88 VNIFLRQQWNDPRLAYNEYPDDS---LDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRIS 149

  Fly   166 HDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTEIELPQ 230
            .:..:||..::||.|:|.|..:::|.|.|.|.|.:||..:|:.||:|.|.....:.|...:.|||
Mouse   150 RNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQ 214

  Fly   231 LDISN----NYTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEA 291
            ..:..    .|   ||..|:||.|||:...|:|.|::||:|...||||.|||::|||||||..:|
Mouse   215 FILKEEKDLRY---CTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDA 276

  Fly   292 IPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVN-------- 348
            .||||.||:|::||:.||::.|:.|||.||||||||:||:.|.:|||.:|:|:|.||
Mouse   277 APARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKE 341

  Fly   349 -----------------------------NF----MGPVATKA-----MKGYSDENISDLDDLKS 375
                                         ||    |||...:|     :||.::.|.::.....|
Mouse   342 LLRFRRKRRHHKSPMLNLFQDDEGGEGRFNFSAYGMGPACLQAKDGISVKGANNNNTTNPPPAPS 406

  Fly   376 -ALQHHRESIIEPQYDTFCHGHATAIYIDKFSRFFFPFSFFILNIVYWTTF 425
             :.:..|:..|:           .|..|||.||..||.:|.|.|:.||..:
Mouse   407 KSPEEMRKLFIQ-----------RAKKIDKISRIGFPMAFLIFNMFYWIIY 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	70/189 (37%)
		Cys-loop	182..196	CDD:349793	5/13 (38%)
		LGIC_TM_anion	265..>351	CDD:349851	53/126 (42%)
		TM1 helix	265..288	CDD:349851	15/22 (68%)
		TM2 helix	292..316	CDD:349851	12/23 (52%)
		TM3 helix	324..350	CDD:349851	15/62 (24%)
Glra1	NP_001277750.1	LIC	7..446	CDD:273305	158/439 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..410		4/18 (22%)