Protein Alignment HisCl1 and Gabrg2

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_032099.1
• Gene: Gabrg2 / 14406
• MGIID: 95623
• Length: 474
• Species: Mus musculus
• Alignment Length: 399
• Identity: 125/399 - (31%)
• Similarity: 211/399 - (52%)
• Gaps: 41/399 - (10%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131
            ||....|.:..:||:::..:.|.|:..:|..:|.|..|||.||:|.|.||:.  |.:.:...|:.
Mouse    76 YDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKF--NSTIKVLRLNS 138

  Fly   132 DWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQIC 196
            :.:..||.||.||:|:||...|.::.||..|.:::|..:||..:||:...|.::..::|.|...|
Mouse   139 NMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSC 203

  Fly   197 SMMIESLSHTVEDLVFIWNMTDPLVVNTEI-ELPQLDISNNYTTDCTIEYSTGNFTCLAIVFNLR 260
            .:...|..:..|::|:.|..:...|.:|.. .|.|........|...::.::|::..:::.|:|.
Mouse   204 PLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLS 268

  Fly   261 RRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKA 325
            ||:||....||||..||||:||:||||..:|:|||.:||:|::||:.|.:|.:::|||.||||.|
Mouse   269 RRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTA 333

  Fly   326 IDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDEN-----------ISDLDDLKSALQ- 378
            :|:::|.|.:|||.:|:|:..::.|:........|....:|           ..|:....:.:|
Mouse   334 MDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQM 398

  Fly   379 ----HHRESIIEPQYDT---------FC-----------HG--HATAIYIDKFSRFFFPFSFFIL 417
                |.:|...|..|:.         ||           ||  |.....:|.::|.|||.:|.:.
Mouse   399 NNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLF 463

  Fly   418 NIVYWTTFL 426
            |:|||.::|
Mouse   464 NLVYWVSYL 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	52/184 (28%)
		Cys-loop	182..196	CDD:349793	3/13 (23%)
		LGIC_TM_anion	265..>351	CDD:349851	42/85 (49%)
		TM1 helix	265..288	CDD:349851	14/22 (64%)
		TM2 helix	292..316	CDD:349851	10/23 (43%)
		TM3 helix	324..350	CDD:349851	9/25 (36%)
Gabrg2	NP_032099.1	LIC	68..471	CDD:455710	124/396 (31%)
		LGIC_ECD_GABAAR_G	89..270	CDD:349801	51/182 (28%)
		Cys-loop	189..203	CDD:349801	3/13 (23%)