Protein Alignment HisCl1 and Gabrd

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: XP_006538609.2
• Gene: Gabrd / 14403
• MGIID: 95622
• Length: 483
• Species: Mus musculus
• Alignment Length: 417
• Identity: 126/417 - (30%)
• Similarity: 196/417 - (47%)
• Gaps: 78/417 - (18%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131
            |.:|..|.:.|.|..|...:.|.|:|.|:|.:|.|...:||.|||||.||..  |.:.:...||.
Mouse    85 YARNFRPGIGGAPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSY--NHTNETLGLDS 147

  Fly   132 DWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQIC 196
            .::..:|.||.|..|||...||::::.|..:.|..|..:||..::|..::|.|....||.|.|.|
Mouse   148 RFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPLDEQEC 212

  Fly   197 SMMIESLSHTVEDLVFIWNMTDPLVVNTE-IELPQLDI-SNNYTTDCTIEYSTGNFTCLAIVFNL 259
            .:.:||..::.||:|:.|:.....:...: ::|.|..| |..:||:.....|.|.|..|::.|.|
Mouse   213 MLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFQL 277

  Fly   260 RRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVK 324
            ||..|.::..:|:||.|:|.|||:||||...|:||||:||:|::||:.|....::.|||..|.:|
Mouse   278 RRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIK 342

  Fly   325 AIDVWMSSCSVFVFLSLMEFA-------------------------------------------- 345
            |:||:...|.||||.:|:|:|
Mouse   343 ALDVYFWICYVFVFAALVEYAFAHFNADYRKKRKAKVKVTKPRAEMDVRNAIVLFSLSAAGVSQE 407

  Fly   346 -VVNNFMGPVATKAMKGYSDENISDLDD----------LKSALQHHRESIIEP-QYDTFCHGHAT 398
             .::...|.|....|..|....:....:          ::|.|        :| ..||
Mouse   408 LAISRRQGRVPGNLMGSYRSVEVEAKKEGGSRPGGPGGIRSRL--------KPIDADT------- 457

  Fly   399 AIYIDKFSRFFFPFSFFILNIVYWTTF 425
               ||.::|..||.:|..:||:||..:
Mouse   458 ---IDIYARAVFPAAFAAVNIIYWAAY 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	66/196 (34%)
		Neur_chan_memb	270..>350	CDD:280999	39/124 (31%)
Gabrd	XP_006538609.2	LGIC_ECD	97..280	CDD:355788	62/184 (34%)
		Cys-loop	198..212	CDD:349787	6/13 (46%)
		LGIC_TM_GABAAR_delta	283..>371	CDD:349857	39/87 (45%)
		TM1 helix	286..306	CDD:349857	11/19 (58%)
		TM2 helix	315..336	CDD:349857	7/20 (35%)
		TM3 helix	346..368	CDD:349857	9/21 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810