Protein Alignment HisCl1 and Gabrb2

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001334243.1
• Gene: Gabrb2 / 14401
• MGIID: 95620
• Length: 512
• Species: Mus musculus
• Alignment Length: 472
• Identity: 137/472 - (29%)
• Similarity: 217/472 - (45%)
• Gaps: 115/472 - (24%)

  Fly    65 KTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLR---LPENMSEQY 126
            |.||....|...|.|..|..::.:.|:|.::|.:|.|...::..|:|||.||.   :|.|::...
Mouse    45 KGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDN 109

  Fly   127 RILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPH 191
            |:.|     .:|.||.:|.|.||...|.:::.|..:.|:.|.|:||..::|...:|.|....||.
Mouse   110 RVAD-----QLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPL 169

  Fly   192 DTQICSMMIESLSHTVEDLVFIWNMTDPLVVN-TEIELPQLDISNNYTTDCTIEYSTGNFTCLAI 255
            |.|.|::.|||..:|.:|:.|.|...|..|.. |:|||||..|.:.......:.:|||::..|::
Mouse   170 DEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSL 234

  Fly   256 VFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPV 320
            .|.|:|.:||.:..||:||.||.::||:||||..:|..|||.||:|::||:.|.||..:::||.:
Mouse   235 SFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299

  Fly   321 SYVKAIDVWMSSCSVFVFLSLMEFAVVNNFM---GP-----VATKAMKGYSDENISDLD-----D 372
            .||||||:::..|.||||::|:|:|:||...   ||     .|.||....:::...|::     |
Mouse   300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAANANNEKMRLDVNKMFYKD 364

  Fly   373 LKSALQHHR----------------------------ESII--------------------EPQY 389
            :|.....:|                            |:|:                    :|:.
Mouse   365 IKQNGTQYRSLWDPTGDLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRS 429

  Fly   390 DTFCHGHATAIY---------------------------------------------IDKFSRFF 409
            ....:..::..|                                             ||::||.|
Mouse   430 TMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIF 494

  Fly   410 FPFSFFILNIVYWTTFL 426
            ||..|...|||||..::
Mouse   495 FPVVFSFFNIVYWLYYV 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	61/187 (33%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	43/85 (51%)
		TM1 helix	265..288	CDD:349851	12/22 (55%)
		TM2 helix	292..316	CDD:349851	11/23 (48%)
		TM3 helix	324..350	CDD:349851	14/25 (56%)
Gabrb2	NP_001334243.1	LIC	9..510	CDD:455710	137/469 (29%)