Protein Alignment HisCl1 and pHCl-1

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: XP_061508178.1
• Gene: pHCl-1 / 1276287
• VectorBaseID: AGAMI1_005729
• Length: 883
• Species: Anopheles gambiae
• Alignment Length: 395
• Identity: 112/395 - (28%)
• Similarity: 174/395 - (44%)
• Gaps: 67/395 - (16%)

  Fly    13 CLIALAIYLHAL------EQSIQHCHCVHG---YRNNTESAELVSH------YESSLSLPDI--- 59
            ||.|.:..|.||      ..:....|.:.|   :.......|::.|      |:..| ||.:
Mosquito   260 CLYAASSVLLALCYLTIPTVASDTAHPIRGRVRFAEGKSDKEILDHLLKNSRYDKRL-LPPVDDA 323

  Fly    60 -------LPIPSKTYDKNRAPKLLGQP-----TVVYFHVTVLSLDSINEESMTYVTDIFLAQSWR 112
                   .|..:|.....|.|   |:|     ..|...|.:|||.|.:|.|:.|..:..|.|.|.
Mosquito   324 DFCCGMHTPEMAKHIPDMRVP---GRPQNRGTLTVNVSVLLLSLASPDESSLKYEVEFLLQQQWF 385

  Fly   113 DPRLRLPENMSEQYRILDVDWLH-SIWRPDCFFKNAKKVTFHEMSIPNHY-LWLYHDKTLLYMSK 175
            |||||. .|.| ||..|:....| .||.||.:|  .....|.:..||.|: |.:|.:.|:.|:.:
Mosquito   386 DPRLRY-ANQS-QYEYLNAIHHHEDIWLPDTYF--IMHGDFKDPIIPMHFALRIYRNGTINYLMR 446

  Fly   176 LTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIW-NMTDPLVVNTEIELPQLDISNNYTT 239
            ..|:|||..:...:|.|..:||..:||:|:....:.::| |..|.|..:..:......:..|.|.
Mosquito   447 RHLILSCQGRLNIFPFDDPLCSFALESISYEQSAITYVWKNDEDTLRKSPSLTTLNAYLIQNQTI 511

  Fly   240 DCTIEYS--------------------------TGNFTCLAIVFNLRRRLGYHLFHTYIPSALIV 278
            .|.|:.|                          .||::||.:.....|...::....:||..::|
Mosquito   512 ACPIKASWRAEGQTLSVEDEEFLCNLCQRRFEEQGNYSCLKVDLIFTRDRAFYFTTVFIPGIILV 576

  Fly   279 VMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLME 343
            ..|:|:||::..|:|||..:|||::|...|.:...:.:||.||.:.|::||...|..|::.||:|
Mosquito   577 TSSFITFWLEWNAVPARSMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLE 641

  Fly   344 FAVVN 348
            |..||
Mosquito   642 FVCVN 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	61/217 (28%)
		Cys-loop	182..196	CDD:349793	3/13 (23%)
		LGIC_TM_anion	265..>351	CDD:349851	31/84 (37%)
		TM1 helix	265..288	CDD:349851	7/22 (32%)
		TM2 helix	292..316	CDD:349851	8/23 (35%)
		TM3 helix	324..350	CDD:349851	11/25 (44%)
pHCl-1	XP_061508178.1	None