Protein Alignment HisCl1 and Gabra5

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001349090.1
• Gene: Gabra5 / 110886
• MGIID: 95617
• Length: 463
• Species: Mus musculus
• Alignment Length: 403
• Identity: 130/403 - (32%)
• Similarity: 192/403 - (47%)
• Gaps: 55/403 - (13%)

  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131
            ||....|.|..:.|.|...:.|.|...:::..|.|..|:|..|||:|.|||....|..    |.:
Mouse    60 YDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQR----LPL 120

  Fly   132 DWL--HSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194
            :.|  ..||.||.||.|.||...|.|:.||..|.|..|.||||..:||:...|.|:.|.:|.|..
Mouse   121 NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAH 185

  Fly   195 ICSMMIESLSHTVEDLVFIW--NMTDPLVVNTE-IELPQLDISNNYTTDCTIEYSTGNFTCLAIV 256
            .|.:...|.::...::|::|  ..|..:||..: ..|.|..:.........|..|||.:|.:...
Mouse   186 ACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAH 250

  Fly   257 FNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVS 321
            |:|:|::||.:..||:|..:.|::|.:|||:..|::|||...|||::||:.|.:..::.|||.|:
Mouse   251 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVA 315

  Fly   322 YVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDENISDLDDLKSALQHHRESIIE 386
            |..|:|.:::.|..|||.:|:|||.||.|     ||  :|::.:....|:..| ..:..||.|:.
Mouse   316 YATAMDWFIAVCYAFVFSALIEFATVNYF-----TK--RGWAWDGKKALEAAK-IKKKERELILN 372

  Fly   387 PQYDTFCHGHAT---------------------------------AIY-----IDKFSRFFFPFS 413
            ...:.|..|..|                                 ..|     |||.||..||..
Mouse   373 KSTNAFTTGKLTHPPNIPKEQPPAGTANAPTVSIKASEEKTAESKKTYNSISKIDKMSRIVFPIL 437

  Fly   414 FFILNIVYWTTFL 426
            |...|:|||.|:|
Mouse   438 FGTFNLVYWATYL 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	65/199 (33%)
		Neur_chan_memb	270..>350	CDD:280999	35/79 (44%)
Gabra5	NP_001349090.1	LIC	15..449	CDD:273305	128/400 (32%)
		LGIC_ECD_GABAAR_A5	58..256	CDD:349839	65/199 (33%)
		Cys-loop	173..187	CDD:349839	5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..408		0/20 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810